Bicalutamide EP Impurity D

Basic Information

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CAS Number

654-70-6

Molecular Formula

C8H5F3N2

Molecular Weight

186.13 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Nitriles

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Melting Point

141.0 to 144.0 deg-C

Boiling Point

294.5°C at 760 mmHg

Density

1.3700

Flash Point

131.9±27.3 °C

Refractive Index

1.499

Vapor Pressure

0.0±0.6 mmHg at 25°C

SMILES

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C1=CC(=C(C=C1N)C(F)(F)F)C#N

InChI

InChI=1S/C8H5F3N2/c9-8(10,11)7-3-6(13)2-1-5(7)4-12/h1-3H,13H2

InChIKey

PMDYLCUKSLBUHO-UHFFFAOYSA-N

LogP

2.74048

Complexity

227

Safety Information

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GHS Hazard Pictograms

H302

H317

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H317 May cause an allergic skin reaction
Sensitization, Skin

Hazard Class

Class 6.1 Class 6.1

Synonyms & References

English

4-Amino-2-trifluromethyl benzonitrile
4-Amino-2-trifluoromethylbenzonitrile
Bicalutamide Imp. D (EP); 4-Amino-2-(trifluoromethyl)benzonitrile; 5-Amino-2-cyanobenzotrifluoride; Bicalutamide Impurity D
4-Amino-alpha,alpha,alpha-trifluoro-o-tolunitrile
InChI=1/C8H5F3N2/c9-8(10,11)7-3-6(13)2-1-5(7)4-12/h1-3H,13H2
5-amino2-cyanobenzotrifluoride
4-amino-2-trifluoromethyl-benzonitrile
4-Amino-2-(trifluoromethyl)benzonitrile, 97%
UNII-L47D9XHC08
3-trifluoromethyl-4-cyano-aniline
A1213
4-cyano-3-(trifluoromethyl)aniline
FT-0652695
O-TOLUNITRILE, 4-AMINO-.ALPHA.,.ALPHA.,.ALPHA.-TRIFLUORO-
5-Aminno-2-cyanobenzotrifluoride
A8877
SCHEMBL110567
MFCD00042155
AKOS005063751
Benzonitrile, 4-amino-2-(trifluoromethyl)-
Bicalutamide Impurity D
PMDYLCUKSLBUHO-UHFFFAOYSA-
AB01894
CS-M3188
NS00003763
EC 700-293-1
PS-8479
4-amino-2-trifluoromethyl benzonitrile
L47D9XHC08
4-AMINO-.ALPHA.,.ALPHA.,.ALPHA.-TRIFLUORO-O-TOLUNITRILE
Q27282680

MDL Number

MFCD00042155

Customs Code

2926909090

FAQ

What is Bicalutamide EP Impurity D (CAS: 654-70-6)?

Bicalutamide EP Impurity D (CAS: 654-70-6) is a pharmaceutical impurity associated with the drug Bicalutamide, a nonsteroidal anti-androgen used in prostate cancer treatment. It is a structural variant or degradation product of the parent compound, typically identified during quality control processes. The chemical formula is C20H24N2O, and it exhibits properties similar to Bicalutamide, including solubility in organic solvents. Its presence is monitored to ensure drug purity and safety.

What are the main uses of Bicalutamide EP Impurity D (CAS: 654-70-6)?

Bicalutamide EP Impurity D (CAS: 654-70-6) is primarily used in pharmaceutical research and quality control to identify and quantify impurities in Bicalutamide formulations. It serves as a reference standard for analytical testing and regulatory compliance. Additionally, it may be employed in drug development to study impurity profiles and their impact on therapeutic efficacy and safety. Its applications are limited to non-therapeutic purposes in laboratories and manufacturing.

Is Bicalutamide EP Impurity D (CAS: 654-70-6) safe?

Bicalutamide EP Impurity D (CAS: 654-70-6) is not intended for therapeutic use and its safety profile is less established compared to the parent drug. However, it is generally considered safe in trace amounts when handled properly. Precautions include wearing protective gloves and ensuring adequate ventilation during handling. Safety standards for pharmaceutical impurities, such as ICH Q3A, emphasize minimizing exposure and adhering to controlled environments to prevent health risks.

How should Bicalutamide EP Impurity D (CAS: 654-70-6) be stored?

Bicalutamide EP Impurity D (CAS: 654-70-6) should be stored in a cool, dry place (25°C), protected from light, and kept in an airtight container. It is recommended to maintain low humidity levels to ensure stability and prevent degradation. Storage in a desiccator is ideal to avoid moisture absorption. Always follow safety guidelines for handling chemical impurities to maintain product integrity and user safety.