4-Amino-2-hydroxybenzoic acid

Basic Information

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CAS Number

65-49-6

Molecular Formula

C7H7NO3

Molecular Weight

153.14 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Physical State

Powder

Melting Point

135-145 °C

Boiling Point

276.03°C (rough estimate)

Density

1.3585 (rough estimate)

Water Solubility

2 g/L (20 ºC)

Flash Point

184.1℃

Solubility

1.69g/l

Refractive Index

1.5500 (estimate)

Vapor Pressure

0.0±0.9 mmHg at 25°C

SMILES

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C1=CC(=C(C=C1N)O)C(=O)O

InChI

InChI=1S/C7H7NO3/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3,9H,8H2,(H,10,11)

InChIKey

WUBBRNOQWQTFEX-UHFFFAOYSA-N

LogP

0.6726000000000001

pKa

3.25(at 25℃)

Topological Polar Surface Area

83.55000000000001 Å²

Hydrogen Bond Donor/Acceptor

4 / 4

Complexity

160

Safety Information

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GHS Hazard Pictograms

H319

Hazard Statement

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Sensitiveness

Sensitive to light and air

Toxicity

LD50 orally in mice: 4 g/kg (Bavin)

Synonyms & References

English

HMS3371A17
SMR000058830
BDBM48319
KBio1_000350
NSC 2083
NIH 2939
Salicyclic acid, 4-amino-
para-aminosalicylic acid;Aminosalicylic acid;4-aminosalicylate
Rezipas
Pasnodia
4-AMINO,2-HYDROXY-BENZOIC ACID
Parasalindon
-aminosalicylic acid
p-Aminosalicylic acid STANDARD
HMS3715M08
SBI-0051279.P004
Spectrum_000042
AMINOSALICYLATE SODIUM
cid_11988145
EINECS 200-613-5
D0Q8UR
4-Carboxy-3-hydroxyaniline
KBioGR_000590
PASK
Amino-pas
HMS501B12
C02518
HSDB 3203
Pasem
Kyselina p-aminosalicylova
NCGC00018110-03

MDL Number

MFCD00007789

Customs Code

29225000

FAQ

What is 4-Amino-2-hydroxybenzoic acid (CAS: 65-49-6)?

4-Amino-2-hydroxybenzoic acid, also known as aminosalicylic acid, is a compound with the chemical formula C7H7NO3. It is a white crystalline solid that is soluble in water and has acidic properties due to the carboxylic acid group. This compound is commonly used in various chemical applications due to its versatile functional groups.

What are the main uses of 4-Amino-2-hydroxybenzoic acid (CAS: 65-49-6)?

4-Amino-2-hydroxybenzoic acid is widely used in pharmaceuticals as a precursor for drugs like sulfasalazine. It also finds applications in the synthesis of dyes, pharmaceutical intermediates, and other organic compounds. Its use in food additives and research is limited, primarily due to its chemical reactivity and specific functional groups.

Is 4-Amino-2-hydroxybenzoic acid (CAS: 65-49-6) safe?

4-Amino-2-hydroxybenzoic acid is generally considered safe when handled properly. However, it may cause skin and eye irritation. Safety standards recommend using protective gloves and goggles, and proper ventilation. It is important to follow standard chemical safety protocols to ensure safe handling and use.

How should 4-Amino-2-hydroxybenzoic acid (CAS: 65-49-6) be stored?

4-Amino-2-hydroxybenzoic acid should be stored in a cool, dry, and well-ventilated place, away from light. It is best kept in a sealed container to prevent moisture absorption. Storage at temperatures below 25°C is recommended to maintain stability and prolong shelf life.