6-O-Benzyl-4-dehydroxy-4-diMethylphenylsilyl Entecavir | CAS No. 649761-24-0

6-O-Benzyl-4-dehydroxy-4-diMethylphenylsilyl Entecavir

Basic Information

CAS Number

649761-24-0

Molecular Formula

C27H31N5O2Si

Molecular Weight

485.66 g/mol

AD

Basic Physical Properties

C[Si](C)(C1CC(C(=C)C1COCC2=CC=CC=C2)N3C=NC4=C3N=C(NC4=O)N)C5=CC=CC=C5

InChI

InChI=1S/C27H31N5O2Si/c1-18-21(16-34-15-19-10-6-4-7-11-19)23(35(2,3)20-12-8-5-9-13-20)14-22(18)32-17-29-24-25(32)30-27(28)31-26(24)33/h4-13,17,21-23H,1,14-16H2,2-3H3,(H3,28,30,31,33)/t21-,22-,23-/m0/s1

InChIKey

LMLFXMXUWHGHSR-VABKMULXSA-N

LogP

4.021600000000001

Topological Polar Surface Area

98.82 Ų

Hydrogen Bond Donor/Acceptor

3 / 7

Complexity

820

Synonyms & References

English

  • 6-O-Benzyl-4-dehydroxy-4-dimethylphenylsilyl Entecavir
  • 2-amino-9-((1S,3R,4S)-3-((benzyloxy)methyl)-4-(dimethyl(phenyl)silyl)-2-methylenecyclopentyl)-1H-purin-6(9H)-one
  • ENTECAVIR RELATED COMPOUND A (IMPURITY F)
  • 2-Amino-9-[(1S,3R,4S)-3-[(benzyloxy)methyl]-4-[dimethyl(phenyl)silyl]-2-methylidenecyclopentyl]-1,9-dihydro-6H-purin-6-one
  • 2-Amino-9-[(1S,3R,4S)-4-(dimethylphenylsilyl)-2-methylene-3-[(phenylmethoxy)methyl]cyclopentyl]-1,9-dihydro-6H-purin-6-one
  • 9-[(1S,3R,4S)-4-Dimethylphenylsilyl-3-(benzyloxymethyl)-2-methylenecyclopentyl]guanine
  • Entecavir Related Compound A
  • UNII-LTP7YND4GS
  • 2-Amino-9-((1S,3R,4S)-3-((benzyloxy)methyl)-4-(dimethyl(phenyl)silyl)-2-methylenecyclopentyl)-1H-purin-6(9H)-one
  • 6H-Purin-6-one, 2-amino-9-((1S,3R,4S)-4-(dimethylphenylsilyl)-2-methylene-3-((phenylmethoxy)methyl)cyclopentyl)-1,9-dihydro-
  • 3-Benzyl-4-silyl entecavir
  • 9-((1S,3R,4S)-4-Dimethylphenylsilyl-3-(benzyloxymethyl)-2-methylenecyclopentyl)guanine
  • SCHEMBL12527744
  • LTP7YND4GS
  • AMY38911
  • 6H-Purin-6-one, 2-amino-9-[(1S,3R,4S)-4-(dimethylphenylsilyl)-2-methylene-3-[(phenylmethoxy)methyl]cyclopentyl]-1,9-dihydro-
  • 2-AMINO-9-{(1S,3R,4S)-3-[(BENZYLOXY)METHYL]-4-[DIMETHYL(PHENYL)SILYL]-2-METHYLIDENECYCLOPENTYL}-9H-PURIN-6(1H)-ONE
  • 6-O-Benzyl-4-dehydroxy-4-diMethylphenylsilyl Entecavir
  • 649761-24-0
  • ENTECAVIR MONOHYDRATE IMPURITY F [EP IMPURITY]
  • 2-Amino-9-[(1S,3R,4S)-4-[dimethyl(phenyl)silyl]-2-methylidene-3-(phenylmethoxymethyl)cyclopentyl]-1H-purin-6-one
  • 2-Amino-9-((1S,3R,4S)-4-(dimethylphenylsilyl)-2-methylene-3-((phenylmethoxy)methyl)cyclopentyl)-1,9-dihydro-6H-purin-6-one

MDL Number

MFCD04969015

FAQ

What is 6-O-Benzyl-4-dehydroxy-4-diMethylphenylsilyl Entecavir (CAS: 649761-24-0)?

6-O-Benzyl-4-dehydroxy-4-diMethylphenylsilyl Entecavir is a chemical compound with CAS number 649761-24-0. It is a key intermediate in the synthesis of Entecavir, a nucleoside analog used in the treatment of hepatitis B virus (HBV) infections.

What are the main uses of 6-O-Benzyl-4-dehydroxy-4-diMethylphenylsilyl Entecavir (CAS: 649761-24-0)?

6-O-Benzyl-4-dehydroxy-4-diMethylphenylsilyl Entecavir is primarily used in the pharmaceutical industry as an intermediate for synthesizing Entecavir, a drug that targets the hepatitis B virus (HBV) and is used to treat chronic hepatitis B.

Is 6-O-Benzyl-4-dehydroxy-4-diMethylphenylsilyl Entecavir (CAS: 649761-24-0) safe?

6-O-Benzyl-4-dehydroxy-4-diMethylphenylsilyl Entecavir is generally safe when handled under appropriate conditions. However, it should be used with caution, and individuals should follow all safety guidelines, including wearing protective gloves and eye wear, to prevent skin and eye irritation.

How should 6-O-Benzyl-4-dehydroxy-4-diMethylphenylsilyl Entecavir (CAS: 649761-24-0) be stored?

6-O-Benzyl-4-dehydroxy-4-diMethylphenylsilyl Entecavir should be stored in a cool, dry place away from direct sunlight and heat sources. It should be kept in a sealed container to protect it from moisture and contamination. The recommended storage temperature is between 15-25°C (59-77°F).

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