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(2R)-1-({4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl}oxy)-2-propanyl L-alaninate | CAS No. 649735-63-7

(2R)-1-({4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl}oxy)-2-propanyl L-alaninate

Basic Information

Chemical_Structure_Of
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CAS Number

649735-63-7

Molecular Formula

C22H24FN5O4

Molecular Weight

441.46 g/mol

AD

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids
Basic Chemical Raw Materials Organic Chemicals Esters
Basic Chemical Raw Materials Organic Chemicals Ethers
Basic Chemical Raw Materials Organic Chemicals Amines
Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds
Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates
Fine Chemicals Dyes and Pigments Organic Dyes
Fine Chemicals Surfactants Anionic Surfactants
Fine Chemicals Specialty Chemicals UV Stabilizers
Agricultural Chemicals Pesticides Herbicides
Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

SMILES

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CC1=CC2=C(N1)C=CC(=C2F)OC3=NC=NN4C3=C(C(=C4)OCC(C)OC(=O)C(C)N)C

InChI

InChI=1S/C22H24FN5O4/c1-11-7-15-16(27-11)5-6-17(19(15)23)32-21-20-13(3)18(8-28(20)26-10-25-21)30-9-12(2)31-22(29)14(4)24/h5-8,10,12,14,27H,9,24H2,1-4H3/t12-,14+/m1/s1

InChIKey

LTEJRLHKIYCEOX-OCCSQVGLSA-N

LogP

3.4165400000000012

Topological Polar Surface Area

116.76 Ų

Hydrogen Bond Donor/Acceptor

3 / 9

Complexity

660

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral
H360 May damage fertility or the unborn child
Reproductive toxicity

Hazard Class

Class 6.1 Class 6.1

Synonyms & References

English

  • NSC799369
  • J-519933
  • NSC764481
  • U2Y5OFN795
  • CHEMBL270995
  • AC-25066
  • [(2R)-1-[4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[5,1-f][1,2,4]triazin-6-yl]oxypropan-2-yl] (2S)-2-aminopropanoate
  • alaninato de brivanib
  • BMS-582664
  • Brivanib alaninate (BMS-582664)
  • AMY31934
  • DTXSID20215295
  • BRIVANIB L-ALANINE ESTER [MI]
  • L-Alanine, (1R)-2-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-5- methylpyrrolo(2,1-f)(1,2,4)triazin-6-yl)oxy)-1-methylethyl ester
  • EX-A012
  • (1R)-2-[[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]-1-methylethyl (2S)-2-aminopropanoate
  • brivanib alinate
  • Brivanib alaninate,BMS-582664
  • (S)-((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[1,2-f][1,2,4]triazin-6-yloxy)propan-2-yl) 2-aminopropanoate
  • NSC-799369
  • AS-16274
  • BRIVANIB ALANINATE [WHO-DD]
  • DB11865
  • D08878
  • (2R)-1-({4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl}oxy)propan-2-yl (2S)-2-aminopropanoate
  • NCGC00386131-01
  • BRIVANIB ALANINATE [JAN]
  • alaninate de brivanib
  • (1R,2S)-2-aminopropionic acid 2-[4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy]-1-methylethyl ester
  • BRIVANIB ALANINATE [USAN]
  • BMS582664

MDL Number

MFCD22577162

Customs Code

2933990090

FAQ

What is (2R)-1-({4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl}oxy)-2-propanyl L-alaninate (CAS: 649735-63-7)?
(2R)-1-({4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl}oxy)-2-propanyl L-alaninate is a complex organic compound with a unique molecular structure. It includes a propanoyl group, a pyrrolo[2,1-f][1,2,4]triazine derivative, and a 1H-indole moiety. This compound is characterized by its structural complexity and potential for use in medicinal and pharmaceutical applications due to its chemical and biological properties.

What are the main uses of (2R)-1-({4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl}oxy)-2-propanyl L-alaninate (CAS: 649735-63-7)?
(2R)-1-({4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl}oxy)-2-propanyl L-alaninate is primarily used in the pharmaceutical industry for its potential as a drug candidate. It is also explored in research for its biological activities and may have applications in treating certain diseases, though its specific uses are limited and currently under investigation.

Is (2R)-1-({4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl}oxy)-2-propanyl L-alaninate (CAS: 649735-63-7) safe?
(2R)-1-({4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl}oxy)-2-propanyl L-alaninate is considered safe under controlled conditions, but it requires handling with caution due to its chemical complexity. Proper protective measures, such as gloves and goggles, should be worn during handling. It is important to follow all safety guidelines and regulatory standards to ensure safe use and disposal.

How should (2R)-1-({4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl}oxy)-2-propanyl L-alaninate (CAS: 649735-63-7) be stored?
(2R)-1-({4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl}oxy)-2-propanyl L-alaninate should be stored in a cool, dry place away from direct sunlight and heat sources. It should be kept in a tightly sealed container to prevent degradation. The storage temperature should not exceed 25°C, and the relative humidity should be kept below 60%. Proper labeling and documentation of storage conditions are essential for safe handling and use.

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Supplier Information

(2R)-1-({4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl}oxy)-2-propanyl L-alaninate — Shanghai Yuyeh Biotechnology Co., Ltd.

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(2R)-1-({4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl}oxy)-2-propanyl L-alaninate — HePeng （ ShangHai ） Biotechnology Co Ltd

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