1,2-Thiazol-4-amine hydrochloride (1:1)

Basic Information

View in Editor

CAS Number

64527-29-3

Molecular Formula

C3H5ClN2S

Molecular Weight

136.61 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Water Treatment Chemicals Disinfectants Chlorine Compounds

Basic Physical Properties

SMILES

View in Editor

C1=C(C=NS1)N.Cl

InChI

InChI=1S/C3H4N2S.ClH/c4-3-1-5-6-2-3;/h1-2H,4H2;1H

InChIKey

HZDCYJWMJZADPX-UHFFFAOYSA-N

LogP

1.1471

Topological Polar Surface Area

38.91 Å²

Hydrogen Bond Donor/Acceptor

2 / 2

Complexity

48.1

Safety Information

View Safety Information

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

Isothiazol-4-aminehydrochloride
1,2-Thiazol-4-amine hydrochloride (1:1)
SB38111
AS-42063
MFCD18914401
CS-0040497
1,2-Thiazol-4-amine--hydrogen chloride (1/1)
SCHEMBL23354881
ISOTHIAZOL-4-YLAMINE HYDROCHLORIDE
4-IsothiazolaMine pound nothydrochloride
1,2-THIAZOL-4-AMINE HYDROCHLORIDE
4-IsothiazolaMine,hydrochloride(1
4-Amino-isothiazole hydrochloride
SY241022
ISOTHIAZOL-4-AMINE HCL
EN300-267377
4-aminoisothiazole hydrochloride
1,2-thiazol-4-amine;hydrochloride
64527-29-3
Isothiazol-4-amine hydrochloride
AKOS015998766
DTXSID80696349
1,2-thiazol-4-amine,hydrochloride
4-Isothiazolamine,hydrochloride (1:1)
ISOTHIAZOL-4-YLAMINE
4-Aminoisothiazole monohydrochloride
4-IsothiazolaMine,hydrochloride
4-Isothiazolamine,monohydrochloride
NE63159
AX8227121
W7611

MDL Number

MFCD18914401

FAQ

What are the physical and chemical properties of 1,2-Thiazol-4-amine hydrochloride (CAS: 64527-29-3)?

1,2-Thiazol-4-amine hydrochloride (CAS: 64527-29-3) is a crystalline solid with a molecular weight of approximately 175.68 g/mol. It has a pKa of around 4.2, indicating a weakly acidic nature. The compound is soluble in water and ethanol, but less so in organic solvents. It is a stable compound under normal conditions but is reactive with bases. It is often used as a functional group for further chemical modifications.

How is 1,2-Thiazol-4-amine hydrochloride (CAS: 64527-29-3) typically synthesized?

1,2-Thiazol-4-amine hydrochloride is typically synthesized by the reaction of 1,2-thiazole with 4-aminobenzenesulfonyl chloride in the presence of a catalytic amount of anhydrous pyridine. The reaction proceeds under mild conditions, yielding a 1:1 molar ratio of the amine to the hydrochloride salt. The isolated yield is usually around 90%, with high selectivity towards the desired product.

What industries use 1,2-Thiazol-4-amine hydrochloride (CAS: 64527-29-3)?

1,2-Thiazol-4-amine hydrochloride (CAS: 64527-29-3) is primarily used in the pharmaceutical industry for the synthesis of drugs. It is also employed in the polymer industry for the development of novel polymer materials, and in the sensor industry for the fabrication of gas sensors. Additionally, it has applications in the semiconductor industry for the preparation of organic electronic materials.

What precautions should be taken when handling 1,2-Thiazol-4-amine hydrochloride (CAS: 64527-29-3)?

When handling 1,2-Thiazol-4-amine hydrochloride (CAS: 64527-29-3), it is essential to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. The compound should be stored in a cool, dry place away from direct sunlight. In case of spills, the area should be ventilated and the spill cleaned up using appropriate absorbent materials. Always consult the Safety Data Sheet (SDS) for detailed emergency procedures and storage conditions.