1-fluoro-3-methoxy-2-nitrobenzene

Basic Information

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CAS Number

641-49-6

Molecular Formula

C7H6FNO3

Molecular Weight

171.13 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Boiling Point

254.011°C at 760 mmHg

Density

1.322

Flash Point

107.422°C

Refractive Index

1.522

SMILES

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COC1=C(C(=CC=C1)F)[N+](=O)[O-]

InChI

InChI=1S/C7H6FNO3/c1-12-6-4-2-3-5(8)7(6)9(10)11/h2-4H,1H3

InChIKey

GMWOSSBFNSZKAH-UHFFFAOYSA-N

LogP

2.26570

Complexity

171

Synonyms & References

English

J-512463
CS-W003385
2-fluoro-6-methoxy-nitrobenzene
1-Fluoro-3-(methyloxy)-2-nitrobenzene
AKOS009157812
MFCD07368752
TD1307
3-Fluoro-2-nitroanisol
3-Fluoro-2-nitroanisole
3-fluoro-2-nitroanisole, AldrichCPR
SY018981
GMWOSSBFNSZKAH-UHFFFAOYSA-N
AM20050087
A867941
SB38090
641-49-6
1-fluoro-3-methoxy-2-nitrobenzene
Benzene, 1-fluoro-3-methoxy-2-nitro-
2-FLUORO-6-METHOXYNITROBENZENE
GS-4381
SCHEMBL6117
DTXSID70382284
FT-0648667
1-fluoro-3-methoxy-2-nitro-benzene
EN300-133786
2-fluoro-6-methoxynitrobenzene
1-Fluoro-3-methoxy-2-nitrobenzene
KSC307C0P
3-Fluoro-2-nitrophenyl methyl ether
SBB088478
TRA0076279

MDL Number

MFCD07368752

Customs Code

2909309090

FAQ

What are the physical and chemical properties of 1-fluoro-3-methoxy-2-nitrobenzene (CAS: 641-49-6)?

1-Fluoro-3-methoxy-2-nitrobenzene (CAS: 641-49-6) is a crystalline solid with a molecular weight of approximately 200.05 g/mol. It has a low solubility in water but is more soluble in organic solvents like dichloromethane and ethanol. This compound is known for its reactivity towards nucleophiles and reducing agents. It is moderately stable but should be stored in a cool, dry place away from direct sunlight.

How is 1-fluoro-3-methoxy-2-nitrobenzene (CAS: 641-49-6) typically synthesized?

1-Fluoro-3-methoxy-2-nitrobenzene (CAS: 641-49-6) is typically synthesized through the nitration of 3-methoxy-2-fluorobenzene using a nitration mixture. This process is catalyzed by concentrated sulfuric acid. The yield and selectivity can be improved by optimizing reaction conditions such as temperature and concentration of reactants.

What industries use 1-fluoro-3-methoxy-2-nitrobenzene (CAS: 641-49-6)?

1-Fluoro-3-methoxy-2-nitrobenzene (CAS: 641-49-6) is used in the pharmaceutical industry for the synthesis of certain drugs, particularly those that require specific functional groups for their activity. It also finds applications in the production of dyes and pigments. Additionally, it is utilized in the synthesis of materials for sensors and semiconductors due to its unique chemical properties.

What precautions should be taken when handling 1-fluoro-3-methoxy-2-nitrobenzene (CAS: 641-49-6)?

When handling 1-fluoro-3-methoxy-2-nitrobenzene (CAS: 641-49-6), it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be handled in a well-ventilated area or a fume hood to minimize inhalation risk. Spills should be cleaned up using appropriate absorbents and disposed of according to local regulations. A safety data sheet (SDS) should be consulted for detailed information on storage and disposal.