Colchicine | CAS No. 64-86-8

Colchicine

Basic Information

CAS Number

64-86-8

Molecular Formula

C22H25NO6

Molecular Weight

399.44 g/mol

AD

Basic Physical Properties

Melting Point

150-160 °C (dec.)

Boiling Point

726°C at 760 mmHg

Water Solubility

45 g/L (20 ºC)

Flash Point

392.9°C

Solubility

H2O: 10 mg/mL

Refractive Index

1.5614 (estimate)

Vapor Pressure

3.2X10-11 mm Hg at 25 °C (est)

Specific Rotation

-250 º (c=1, alcohol)

CC(=O)NC1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC

InChI

InChI=1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)

InChIKey

IAKHMKGGTNLKSZ-UHFFFAOYSA-N

LogP

2.871600000000001

pKa

12.36(at 20℃)

Topological Polar Surface Area

83.09000000000002 Ų

Hydrogen Bond Donor/Acceptor

1 / 7

Complexity

740

Safety Information

View Safety Information

GHS Hazard Pictograms

H300H300
H340H340

Hazard Statement

H300 Fatal if swallowed
Acute toxicity, oral
H340 May cause genetic defects
Germ cell mutagenicity

Hazard Class

Class 6.1 Class 6.1

Storage Conditions

2-8℃

Toxicity

LD50 in rats (mg/kg): 1.6 i.v. (Rosenbloom, Ferguson); in mice (mg/kg): 4.13 i.v. (Beliles)

Synonyms & References

English

  • UNII-SML2Y3J35T
  • COLCHICINUM [WHO-IP LATIN]
  • DivK1c_000753
  • COLCHICINE COMPONENT OF COLBENEMID
  • (S)-colchicina
  • HMS2096I07
  • COLCHCINE [VANDF]
  • NSC757
  • 7JX9WZ3SJ5
  • Spectrum5_000787
  • CCRIS 691
  • s2284
  • LP00310
  • Prestwick3_000363
  • N-ACETYL TRIMETHYLCOLCHICINIC ACID, METHYL ETHER
  • N-Acetyl trimethylcolchicinic acid methylether
  • Colchicina [Italian]
  • DTXSID5024845
  • HMS1569I07
  • HMS3713I07
  • BDBM50014846
  • N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]acetamide
  • KBio2_006458
  • (1e)-N-[(7s)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl] ethanimidic acid
  • HY-16569
  • Colchisol
  • LS-279
  • BRD-K00259736-001-10-7
  • NCGC00025125-15
  • N-[(7S,12aP)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide
  • Condylon

MDL Number

MFCD00078484

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