4-(Benzyloxy)aniline

Basic Information

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CAS Number

6373-46-2

Molecular Formula

C13H13NO

Molecular Weight

199.25 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Physical Properties

Physical State

Solid

Melting Point

52.0 to 56.0 deg-C

Boiling Point

155°C/3mmHg

SMILES

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C1=CC=C(C=C1)COC2=CC=C(C=C2)N

InChI

InChI=1S/C13H13NO/c14-12-6-8-13(9-7-12)15-10-11-4-2-1-3-5-11/h1-9H,10,14H2

InChIKey

FIIDVVUUWRJXLF-UHFFFAOYSA-N

LogP

2.847800000000001

Topological Polar Surface Area

35.25 Å²

Hydrogen Bond Donor/Acceptor

2 / 2

Complexity

169

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

NSC59995
4-(benzyloxy)benzenamine
EU-0033351
EINECS 228-917-3
NS00035540
6373-46-2
EN300-35239
A852056
SY037887
QBF5MHJ2MV
CS-W004935
p-(Benzyloxy)aniline
DTXSID00213153
CHEMBL1351571
NSC 59995
SCHEMBL171449
4-Benzyloxyanaline
4-(benzyloxy)benzenamine;4-(Benzyloxy)aniline
HMS1513B03
MLS000100541
4-(phenylmethoxy)-benzenamine
BRN 2101629
WLN: ZR DO1R
AM804177
4-benzoxyaniline
4-Benzyloxyaniline
B5227
Aniline, p-(benzyloxy)-
HMS2258P09
4-benzyloxy-aniline
ChemDiv3_014105

MDL Number

MFCD00025318

Customs Code

2922299090

FAQ

What are the physical and chemical properties of 4-(Benzyloxy)aniline (CAS: 6373-46-2)?

4-(Benzyloxy)aniline is a white crystalline solid with a molecular weight of approximately 202.22 g/mol. It is slightly soluble in water but more soluble in organic solvents like ethanol and acetone. Chemically, it shows basic properties due to the amine group and is prone to nucleophilic substitution and oxidation reactions.

How is 4-(Benzyloxy)aniline (CAS: 6373-46-2) typically synthesized?

4-(Benzyloxy)aniline can be synthesized by the reaction of benzyloxyamine with phenol in the presence of a base such as sodium hydroxide. The process is carried out in a solvent like methanol or ethanol, and the yield is typically around 85-90%. The reaction is selective and efficient.

What industries use 4-(Benzyloxy)aniline (CAS: 6373-46-2)?

4-(Benzyloxy)aniline finds applications in the pharmaceutical industry as a precursor for the synthesis of drugs, in the polymer industry for the preparation of special materials, and in the semiconductor industry for the production of photoresists and other specialty chemicals.

What precautions should be taken when handling 4-(Benzyloxy)aniline (CAS: 6373-46-2)?

Proper personal protective equipment (PPE) including gloves, goggles, and a lab coat should be worn when handling 4-(Benzyloxy)aniline. It should be stored in a well-ventilated area, preferably in a fume hood. In case of spill, it should be carefully cleaned up with appropriate absorbent material, and the area should be thoroughly ventilated. Always refer to the safety data sheet (SDS) for detailed handling and emergency procedures.