5-({4-[(2,3-Dimethyl-2H-indazol-6-yl)(methyl)amino]-2-pyrimidinyl}amino)-2-methylbenzenesulfonamide hydrochloride (1:1)

Basic Information

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CAS Number

635702-64-6

Molecular Formula

C21H24ClN7O2S

Molecular Weight

473.99 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

SMILES

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CN(c1ccc2c(c1)nn(c2C)C)c1ccnc(n1)Nc1ccc(c(c1)S(=O)(=O)N)C.Cl

InChI

InChI=1S/C21H23N7O2S.ClH/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16;/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25);1H

InChIKey

MQHIQUBXFFAOMK-UHFFFAOYSA-N

LogP

3.560840000000001

Topological Polar Surface Area

119.02999999999999 Å²

Hydrogen Bond Donor/Acceptor

3 / 9

Complexity

717

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H332 Harmful if inhaled
Acute toxicity, inhalation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

Pazopanib Hydrochloride
5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide hydrochloride
5-[[4-[(2,3-dimethylindazol-6-yl)-methylamino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide,hydrochloride
5-{4-[(2,3-Dimethyl-2H-indazol-6-yl)-methyl-amino]-pyrimidin-2-ylamino}-2-methyl-benzenesulfonamide hydrochloride
Benzenesulfonamide, 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-m...
GW786034
PAZOPANIB
Pazopanib HCL
Pazopanib HCl (GW786034 HCl)
Pazopanib HCl (GW786034 HCl, Armala®, Votrient®)
Armala
GW-786034
Pazopanib (Hydrochloride)
UNII-33Y9ANM545
Votrient
GW786034B
pazopanib monohydrochloride
GW 786034
GW786034 HCl
33Y9ANM545
AK163181
S1035
C21H23N7O2S.HCl
5-((4-((2,3-DIMETHYL-2H-INDAZOL-6-YL)(METHYL)AMINO)PYRIMIDIN-2-YL)AMINO)-2-METHYLBENZENESULFONAMIDE HYDROCHLORIDE
5-[[4-[(2,3-dimethylindazol-6-yl)-methyl-amino]pyrimidin-2-yl]amino]-2-methyl-benzenesulfonamide hydrochloride
5-((4-((2,3-Dimethyl-2H

MDL Number

MFCD12546138

FAQ

What is 5-({4-[(2,3-Dimethyl-2H-indazol-6-yl)(methyl)amino]-2-pyrimidinyl}amino)-2-methylbenzenesulfonamide hydrochloride (1:1) (CAS: 635702-64-6)?

5-({4-[(2,3-Dimethyl-2H-indazol-6-yl)(methyl)amino]-2-pyrimidinyl}amino)-2-methylbenzenesulfonamide hydrochloride (1:1), with CAS number 635702-64-6, is a synthetic organic compound containing a sulfonamide group and a hydrochloride salt. It is characterized by its complex structure, which includes a substituted indazole ring and a pyrimidine moiety. This compound is often used in pharmaceutical research due to its potential biological activity and chemical versatility.

What are the main uses of 5-({4-[(2,3-Dimethyl-2H-indazol-6-yl)(methyl)amino]-2-pyrimidinyl}amino)-2-methylbenzenesulfonamide hydrochloride (1:1) (CAS: 635702-64-6)?

This compound is primarily used in pharmaceutical research as a potential drug candidate, particularly in the development of antitumor and anti-inflammatory agents. Its structure suggests possible applications in medicinal chemistry, where it may serve as a lead molecule for further optimization. It is also utilized in biochemical studies for its interaction properties with various biological targets.

Is 5-({4-[(2,3-Dimethyl-2H-indazol-6-yl)(methyl)amino]-2-pyrimidinyl}amino)-2-methylbenzenesulfonamide hydrochloride (1:1) (CAS: 635702-64-6) safe?

Safety data for this compound is limited, but as a research chemical, it should be handled with standard laboratory precautions. It may pose health risks if inhaled, ingested, or contacted with skin, so appropriate personal protective equipment (PPE) like gloves and goggles is recommended. Always follow safety protocols and regulatory guidelines when working with this compound.

How should 5-({4-[(2,3-Dimethyl-2H-indazol-6-yl)(methyl)amino]-2-pyrimidinyl}amino)-2-methylbenzenesulfonamide hydrochloride (1:1) (CAS: 635702-64-6) be stored?

This compound should be stored in a cool, dry, and dark place, away from moisture and direct light. It is typically kept in a sealed container at a temperature range of 2-8°C. Proper storage helps maintain its chemical stability and prevents degradation. Ensure storage conditions meet safety and quality standards for chemical handling.