Apremilast Impurity 24

Basic Information

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CAS Number

6296-53-3

Molecular Formula

C10H7NO4

Molecular Weight

205.17 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Melting Point

184.0 to 188.0 deg-C

Density

1.512±0.06 g/cm3 (20 ºC 760 Torr),

SMILES

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CC(NC1=CC=CC(C(O2)=O)=C1C2=O)=O

InChI

InChI=1S/C10H7NO4/c1-5(12)11-7-4-2-3-6-8(7)10(14)15-9(6)13/h2-4H,1H3,(H,11,12)

InChIKey

PAUAJOABXCGLCN-UHFFFAOYSA-N

LogP

0.9555999999999999

Topological Polar Surface Area

72.47 Å²

Hydrogen Bond Donor/Acceptor

1 / 5

Complexity

325

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Synonyms & References

English

Acetamide,N-(1,3-dihydro-1,3-dioxo-4-isobenzofuranyl)-
3-Acetamidophthalic anhydride
(S)-2-(3-ethoxy-4-methoxyphenyl)-1-(methylsulphonyl)-eth-2-ylamine-N-acetyl-L-leucine salt
1 WEEK
1,3-Dioxo-2-isoindolineacetic acid
3-ACETYLAMINOPHTHALIC ANHYDRIDE
N-(1,3-dihydro-1,3-dioxo-4-isobenzofuranyl)acetamide
3-acetamidopthalic anhydride
3-acetaminophthalic anhydride
3-acetylamino-phthalic acid-anhydride
3-AcetylaMino-phthalsaeure-anhydrid
N-(1,3-Dihydro-1,3-dioxoisobenzofuran-4-yl)acetamide
N-(1,3-Dioxo-1,3-dihydro-isobenzofuran-4-yl)-acetamide
NSC 16261
NSC 17048
N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide
Acetamide, N-(1,3-dihydro-1,3-dioxo-4-isobenzofuranyl)-
AK162357
N-(1,3-Dioxo-4-isobenzofuranyl)acetamide
NSC16261
3-acetamido-phthalic anhydride
3-Acetylaminophthalsaureanhydrid
N-(1,3-Dioxo-1,3-dihydro-isobenzofuran-4-yl)acetamide
n-(1,3-dioxo-1,3-dihydro-2-b
3-Acetylaminophthalic anhydride
N-(1,3-dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide

MDL Number

MFCD00453138

FAQ

What is Apremilast Impurity 24 (CAS: 6296-53-3)?

Apremilast Impurity 24 (CAS: 6296-53-3) is an impurity found in the drug apremilast. It is a minor byproduct in the synthesis of apremilast and does not have significant therapeutic utility on its own. Its chemical formula is C16H13N3O4S. It is a white to off-white solid with a distinctive odor.

What are the main uses of Apremilast Impurity 24 (CAS: 6296-53-3)?

Apremilast Impurity 24 (CAS: 6296-53-3) is not used for any therapeutic or industrial purposes. It is primarily of interest to pharmaceutical companies for quality control and compliance reasons, as it is a byproduct of the synthesis of the main drug, apremilast. Its presence must be controlled to ensure the quality and safety of apremilast.

Is Apremilast Impurity 24 (CAS: 6296-53-3) safe?

Apremilast Impurity 24 (CAS: 6296-53-3) is safe when handled with appropriate precautions. It is not acutely toxic, but it is important to handle it in a fume hood and wear appropriate personal protective equipment (PPE) such as gloves and goggles. Storage and disposal should follow standard chemical waste protocols to prevent environmental contamination.

How should Apremilast Impurity 24 (CAS: 6296-53-3) be stored?

Apremilast Impurity 24 (CAS: 6296-53-3) should be stored in a cool, dry place, away from direct sunlight and sources of heat. It should be kept in a tightly sealed container to prevent moisture absorption. The storage temperature should be below 25°C, and the relative humidity should be kept below 60%. It is recommended to store it in a refrigerator to maintain stability and prevent degradation.