2-Propoxyphenol

Basic Information

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CAS Number

6280-96-2

Molecular Formula

C9H12O2

Molecular Weight

152.19 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Physical Properties

Boiling Point

227°C (estimate)

Density

1.0523

Flash Point

97.2 °C

Refractive Index

1.5176 (estimate)

SMILES

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CCCOC1=CC=CC=C1O

InChI

InChI=1S/C9H12O2/c1-2-7-11-9-6-4-3-5-8(9)10/h3-6,10H,2,7H2,1H3

InChIKey

JFSVGKRARHIICJ-UHFFFAOYSA-N

LogP

2.1810000000000005

Topological Polar Surface Area

29.46 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Complexity

104

Synonyms & References

English

1-hydroxy-2-propoxybenzene
InChI=1/C9H12O2/c1-2-7-11-9-6-4-3-5-8(9)10/h3-6,10H,2,7H2,1H3
NSC 6186
EINECS 228-484-0
2-propoxy-phenol
MFCD06655033
AI3-08096
DS-5243
EN300-09246
AKOS000271027
2-Propoxyphenol #
D95014
SCHEMBL1805086
J-510293
4-amino-N-(4-methylpyrimidin-2-yl)benzenesulfonamide; 5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine
JFSVGKRARHIICJ-UHFFFAOYSA-
NSC-6186
Phenol, 2-propoxy-
FT-0687050
NSC6186
A834009
6280-96-2
CHEMBL2252443
CS-0152050
Z55993120
NS00035174
DTXSID90211901
HMS1788H05
0-propoxyphenol
2-Propoxyphenol
o-Propoxyphenol

MDL Number

MFCD06655033

Customs Code

2909500000

FAQ

What are the physical and chemical properties of 2-Propoxyphenol (CAS: 6280-96-2)?

2-Propoxyphenol (CAS: 6280-96-2) is a white crystalline solid with a molecular weight of approximately 130.17 g/mol. It has good solubility in water (4.7 g/L at 20°C) and is slightly soluble in ethanol. The compound is known for its reactivity towards nucleophiles and its ability to undergo esterification and condensation reactions. It is stable under normal conditions but should be stored away from strong acids and bases.

How is 2-Propoxyphenol (CAS: 6280-96-2) typically synthesized?

2-Propoxyphenol (CAS: 6280-96-2) is synthesized through the condensation of phenol with propylene oxide. The reaction is typically catalyzed by an acid, such as hydrochloric acid or sulfuric acid, and proceeds with high selectivity. Yield is generally around 90%, and the product is then purified by recrystallization from ethanol.

What industries use 2-Propoxyphenol (CAS: 6280-96-2)?

2-Propoxyphenol (CAS: 6280-96-2) is primarily used in the pharmaceutical industry as a precursor for the synthesis of various drugs. It is also used in the polymer industry for the preparation of epoxy resins and in the cosmetic industry as a raw material for personal care products. Additionally, it has applications in the synthesis of sensors and semiconductors.

What precautions should be taken when handling 2-Propoxyphenol (CAS: 6280-96-2)?

When handling 2-Propoxyphenol (CAS: 6280-96-2), it is essential to use appropriate personal protective equipment (PPE), including gloves, lab coat, and safety goggles. The substance should be used in a well-ventilated area or a fume hood. Spills should be cleaned up with appropriate absorbent materials and disposed of according to local regulations. Always refer to the material safety data sheet (MSDS) for detailed safety information and emergency procedures.