3-Amino-4-fluorophenol

Basic Information

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CAS Number

62257-16-3

Molecular Formula

C6H6FNO

Molecular Weight

127.12 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Boiling Point

269.3℃ at 760 mmHg

SMILES

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C1=CC(=C(C=C1O)N)F

InChI

InChI=1S/C6H6FNO/c7-5-2-1-4(9)3-6(5)8/h1-3,9H,8H2

InChIKey

VJCSFNNTQGRAKH-UHFFFAOYSA-N

LogP

1.1135

Topological Polar Surface Area

46.25 Å²

Hydrogen Bond Donor/Acceptor

3 / 2

Complexity

99.1

Safety Information

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Hazard Statement

Synonyms & References

English

FT-0649778
AC-885
BCP26806
AKOS005063864
VJCSFNNTQGRAKH-UHFFFAOYSA-N
DTXSID20542795
CS-W007503
EN300-117280
Z1201624911
SY022950
SCHEMBL533939
PS-9171
MFCD09033850
3-Amino-4-fluorophenol
J-511614
AM61583
3-amino-4-fluoro-phenol
2-Fluoro-5-hydroxyaniline
62257-16-3
A8606
F2108-0123
Phenol, 3-amino-4-fluoro-
C6H6FNO
2-fluoro-5-hydroxyaniline
5-hydroxy-2-fluoroaniline
Phenol,3-amino-4-fluoro
PubChem4776
KSC898Q9P
WT033
EBD43077
SBB069836

MDL Number

MFCD09033850

Customs Code

2922299090

FAQ

What are the physical and chemical properties of 3-Amino-4-fluorophenol (CAS: 62257-16-3)?

3-Amino-4-fluorophenol is a white crystalline solid with a molecular weight of approximately 161.03 g/mol. It has a pKa of about 9.6. The compound is slightly soluble in water but soluble in polar organic solvents. It is known for its reactivity towards nucleophiles and its ability to form complexes with transition metals. It can be identified by its characteristic UV and IR spectra.

How is 3-Amino-4-fluorophenol (CAS: 62257-16-3) typically synthesized?

3-Amino-4-fluorophenol can be synthesized through the reduction of 3-fluoroaniline with sodium borohydride. The reaction is selective and yields a high purity product. Other routes include the amination of 4-fluorophenol, which can be achieved using a variety of amines and suitable conditions. The choice of method depends on the desired purity and the scale of production.

What industries use 3-Amino-4-fluorophenol (CAS: 62257-16-3)?

3-Amino-4-fluorophenol is primarily used in the pharmaceutical industry as an intermediate for the synthesis of various drugs. It is also utilized in the production of dyes and pigments, and in the development of sensors and semiconductors due to its functional groups. Its applications in polymers are limited but it can be used in the modification of polymer properties.

What precautions should be taken when handling 3-Amino-4-fluorophenol (CAS: 62257-16-3)?

When handling 3-Amino-4-fluorophenol, it is essential to use personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Work in a well-ventilated area or a fume hood to minimize exposure. Spills should be cleaned up using appropriate absorbents and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions and emergency procedures.