3-Amino-4-fluorophenol(CAS: 62257-16-3)

3-Amino-4-fluorophenol is a white crystalline solid with a molecular weight of approximately 161.03 g/mol. It has a pKa of about 9.6. The compound is slightly soluble in water but soluble in polar organic solvents. It is known for its reactivity towards nucleophiles and its ability to form complexes with transition metals. It can be identified by its characteristic UV and IR spectra.

3-Amino-4-fluorophenol can be synthesized through the reduction of 3-fluoroaniline with sodium borohydride. The reaction is selective and yields a high purity product. Other routes include the amination of 4-fluorophenol, which can be achieved using a variety of amines and suitable conditions. The choice of method depends on the desired purity and the scale of production.

3-Amino-4-fluorophenol is primarily used in the pharmaceutical industry as an intermediate for the synthesis of various drugs. It is also utilized in the production of dyes and pigments, and in the development of sensors and semiconductors due to its functional groups. Its applications in polymers are limited but it can be used in the modification of polymer properties.

When handling 3-Amino-4-fluorophenol, it is essential to use personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Work in a well-ventilated area or a fume hood to minimize exposure. Spills should be cleaned up using appropriate absorbents and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions and emergency procedures.