2-Bromo-5-iodopyrazine

Basic Information

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CAS Number

622392-04-5

Molecular Formula

C4H2BrIN2

Molecular Weight

284.88 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

95-97°C

SMILES

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Brc1cnc(I)cn1

InChI

InChI=1S/C4H2BrIN2/c5-3-1-8-4(6)2-7-3/h1-2H

InChIKey

OHTQHZVNZWWYFD-UHFFFAOYSA-N

LogP

1.8437

Topological Polar Surface Area

25.78 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Complexity

80.4

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

2-Bromo-5-iodopyrazine
Pyrazine,2-bromo-5-iodo-
2-Iodo-5-bromopyrazine
5-bromo-2-iodopyrazine
2-bromo-5-iodo-pyrazine
Pyrazine, 2-bromo-5-iodo-
PubChem22622
2-bromanyl-5-iodanyl-pyrazine
SYNQUEST 3H32-S-X3
OHTQHZVNZWWYFD-UHFFFAOYSA-N
SBB054462
CI0015
2-Bromo-5-iodopyrazine, AldrichCPR
RP06672
PB27853
EN000821
BC004810
AB0041829

MDL Number

MFCD08061602

Customs Code

2933990090

FAQ

What are the physical and chemical properties of 2-Bromo-5-iodopyrazine (CAS: 622392-04-5)?

2-Bromo-5-iodopyrazine (CAS: 622392-04-5) is a crystalline solid with a molecular weight of approximately 363.04 g/mol. It has a low solubility in water but is soluble in common organic solvents such as ethanol and acetone. Chemically, it is highly reactive towards nucleophiles and can undergo substitution reactions. It has a molecular structure that makes it suitable for use in synthesis of various organic compounds.

How is 2-Bromo-5-iodopyrazine (CAS: 622392-04-5) typically synthesized?

2-Bromo-5-iodopyrazine (CAS: 622392-04-5) is synthesized via a multi-step process involving bromination and iodination of a pyrazine derivative. Commonly, the reaction is carried out under anhydrous conditions using appropriate solvents like dimethylformamide (DMF) and suitable catalysts. The yield is generally good, and the method is selective for the desired product.

What industries use 2-Bromo-5-iodopyrazine (CAS: 622392-04-5)?

2-Bromo-5-iodopyrazine (CAS: 622392-04-5) is used in pharmaceuticals for the synthesis of novel drug candidates, as well as in the preparation of materials for sensors and semiconductors. Its unique chemical properties make it valuable in developing new compounds with specific functionalities.

What precautions should be taken when handling 2-Bromo-5-iodopyrazine (CAS: 622392-04-5)?

When handling 2-Bromo-5-iodopyrazine (CAS: 622392-04-5), it is essential to use personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. Spills should be cleaned up immediately, and proper disposal procedures should be followed. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions and emergency procedures.