N-(3-hydroxyphenyl)acetamide

Basic Information

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CAS Number

621-42-1

Molecular Formula

C8H9NO2

Molecular Weight

151.17 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Melting Point

145-148 °C

Boiling Point

273.17°C (rough estimate)

Density

1.249

Flash Point

382.6 °C at 760 mmHg

Refractive Index

1.5810 (estimate)

SMILES

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CC(=O)NC1=CC(=CC=C1)O

InChI

InChI=1S/C8H9NO2/c1-6(10)9-7-3-2-4-8(11)5-7/h2-5,11H,1H3,(H,9,10)

InChIKey

QLNWXBAGRTUKKI-UHFFFAOYSA-N

LogP

1.3505999999999998

Topological Polar Surface Area

49.33 Å²

Hydrogen Bond Donor/Acceptor

2 / 3

Complexity

147

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Hazard Class

Class 6.1(b) Class 6.1(b)

Synonyms & References

English

621-42-1
3-Acetamidophenol
Metacetamolo
BS-749
m-(Acetylamino)phenol
V942ZCN81H
Metacetamolum
3-Hydroxyacetanilide
MLS000881183
CCRIS 4567
3-Acetamidophenol, analytical standard
NSC 3990
UNII-V942ZCN81H
KBioGR_000352
SPBio_000473
SR-01000864571-2
NCGC00091423-02
CHEMBL9419
KBio1_001815
AB00216
3'-Hydroxyacetanilide
AB00053402_07
Pedituss
CCG-39594
SR-01000864571
NSC3990
Pharmakon1600-00211175
Metacetamol;3'-Hydroxyacetanilide
Spectrum_000976
N-Acetyl-m-aminophenol
N-(3-Hydroxy-phenyl)-acetamide

MDL Number

MFCD00002263

Customs Code

29242995

FAQ

What regulatory guidelines apply to N-(3-hydroxyphenyl)acetamide (CAS: 621-42-1)?

N-(3-hydroxyphenyl)acetamide (CAS: 621-42-1) must comply with the GHS classification system for hazardous chemicals, which includes criteria for labeling, safety data sheets (SDS), and emergency response. Additionally, it should adhere to REACH regulations in the EU, including notification of substances of very high concern. FDA and EPA have specific requirements for pharmaceutical and environmental applications, respectively, ensuring safe handling and disposal.

Are there alternatives to N-(3-hydroxyphenyl)acetamide (CAS: 621-42-1) in synthesis?

Alternatives to N-(3-hydroxyphenyl)acetamide (CAS: 621-42-1) in synthesis include other acetamides such as N-(4-hydroxyphenyl)acetamide and N-(2-hydroxyphenyl)acetamide. Common alternative reagents include substituted anilines and phenols, which can serve similar functional groups in organic synthesis. These alternatives can provide more sustainable or less hazardous pathways depending on the specific application.

What is the market or research trend for N-(3-hydroxyphenyl)acetamide (CAS: 621-42-1)?

The market for N-(3-hydroxyphenyl)acetamide (CAS: 621-42-1) is growing due to its applications in pharmaceuticals, particularly as an intermediate for antifungal drugs. Research trends focus on developing novel derivatives with enhanced pharmacological properties and exploring its potential in other therapeutic areas. Additionally, there is increasing interest in green chemistry approaches to reduce environmental impact and improve sustainability.

How should waste containing N-(3-hydroxyphenyl)acetamide (CAS: 621-42-1) be handled?

Waste containing N-(3-hydroxyphenyl)acetamide (CAS: 621-42-1) should be collected in appropriate containers and stored safely to prevent environmental contamination. Incineration is a common method for disposal, but professional waste disposal services may be necessary for large quantities. Environmental precautions include monitoring for hazardous emissions and ensuring compliance with local and international regulations. Proper handling and disposal practices are crucial to minimize environmental impact and ensure worker safety.