Benzocaine EP Impurity H

Basic Information

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CAS Number

619-45-4

Molecular Formula

C8H9NO2

Molecular Weight

151.17 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Melting Point

110-111 °C

Boiling Point

299.2°C at 760 mmHg

Density

1.2023 (rough estimate)

Water Solubility

Soluble in alcohol and ether. Slightly soluble in water.

Flash Point

154.9℃

Solubility

3.82g/l

Refractive Index

1.5810 (estimate)

SMILES

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COC(=O)C1=CC=C(C=C1)N

InChI

InChI=1S/C8H9NO2/c1-11-8(10)6-2-4-7(9)5-3-6/h2-5H,9H2,1H3

InChIKey

LZXXNPOYQCLXRS-UHFFFAOYSA-N

LogP

1.0554

Topological Polar Surface Area

52.32 Å²

Hydrogen Bond Donor/Acceptor

2 / 3

Complexity

139

Safety Information

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GHS Hazard Pictograms

H315

H319

H335

Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

AI3-02437
CS-W009283
METHYL P-AMINOBENZOATE
ghl.PD_Mitscher_leg0.22
4-amino methyl benzoate
methyl 4-aminobenzenecarboxylate
methyl p-amino benzoate
BRN 0775913
AM20040876
4-(Carbomethoxy)aniline
methyl-4-amino-benzoate
HMS1732M08
W-105072
A833497
F3377-0763
methyl-p-aminobenzoate
4-carbomethoxy aniline
DTXSID7060704
SCHEMBL42732
4-(Methoxycarbonyl)aniline
Methyl 4-aminobenzoate
4-14-00-01128 (Beilstein Handbook Reference)
4-amino-benzoic acid methylester
BB 0263172
GC4GA4E73E
4-methoxycarbonylaniline
SY017810
4-Aminobenzoic acid methyl ester
Benzoic acid, p-amino-, methyl ester
AKOS000119024
p-Aminobenzoic acid methyl ester

MDL Number

MFCD00007891

Customs Code

2922499990

FAQ

What is Benzocaine EP Impurity H (CAS: 619-45-4)?

Benzocaine EP Impurity H (CAS: 619-45-4) is a chemical compound identified as a specific impurity in the European Pharmacopoeia (EP) version of benzocaine. It has the molecular formula C9H11NO2 and is characterized as a white crystalline solid with limited solubility in water and ethanol. This impurity is commonly detected during the synthesis or purification of benzocaine, which is used as a local anesthetic.

What are the main uses of Benzocaine EP Impurity H (CAS: 619-45-4)?

Benzocaine EP Impurity H (CAS: 619-45-4) is primarily used in pharmaceutical research to identify and quantify impurities in benzocaine production. It may also serve as a reference standard for analytical testing. While not a direct commercial product, its presence is critical for ensuring the purity and safety of pharmaceutical-grade benzocaine, particularly in regulatory compliance and quality control.

Is Benzocaine EP Impurity H (CAS: 619-45-4) safe?

Benzocaine EP Impurity H (CAS: 619-45-4) is generally considered safe when handled properly, but it requires standard safety precautions. Limited toxicity data exists, but as with all chemicals, it should be avoided in high concentrations. Wear protective gloves and goggles, and ensure proper ventilation to prevent inhalation exposure. Adherence to OSHA guidelines is recommended for safe handling.

How should Benzocaine EP Impurity H (CAS: 619-45-4) be stored?

Benzocaine EP Impurity H (CAS: 619-45-4) should be stored in a tightly sealed container in a cool, dry place (ideally 2-8°C) and protected from light. It is stable under these conditions but may degrade if exposed to moisture or high temperatures. Store away from incompatible substances and ensure proper labeling for safe handling and disposal.