1,4-Piperazinediylbis(2,3-dihydro-1,4-benzodioxin-2-ylmethanone) | CAS No. 617677-53-9

1,4-Piperazinediylbis(2,3-dihydro-1,4-benzodioxin-2-ylmethanone)

Basic Information

CAS Number

617677-53-9

Molecular Formula

C22H22N2O6

Molecular Weight

410.43 g/mol

AD

Basic Physical Properties

Density

1.368±0.06 g/cm3 (20 ºC 760 Torr),

Solubility

Insuluble (4.1E-3 g/L) (25 ºC),

O=C(C1COc2c(O1)cccc2)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2

InChI

InChI=1S/C22H22N2O6/c25-21(19-13-27-15-5-1-3-7-17(15)29-19)23-9-11-24(12-10-23)22(26)20-14-28-16-6-2-4-8-18(16)30-20/h1-8,19-20H,9-14H2

InChIKey

RYWJYOGVNZEBKW-UHFFFAOYSA-N

LogP

1.3371999999999988

Topological Polar Surface Area

77.54 Ų

Hydrogen Bond Donor/Acceptor

0 / 8

Synonyms & References

English

  • Doxazosin Related Compound F
  • N,N’-Bis(1,4-benzodioxane-2-carbonyl)piperazine
  • [4-(2,3-dihydro-1,4-benzodioxine-3-carbonyl)piperazin-1-yl]-(2,3-dihydro-1,4-benzodioxin-3-yl)methanone
  • DOXAZOSIN USP RC F
  • N,N'-Bis(1,4-benzodioxane-2-carbonyl)piperazine
  • UNII-VDC41ZG9CP
  • N,N′-Bis(1,4-benzodioxane-2-carbonyl)piperazine
  • piperazine-1,4-diylbis((2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methanone)

MDL Number

MFCD03900355

FAQ

What are the physical and chemical properties of 1,4-Piperazinediylbis(2,3-dihydro-1,4-benzodioxin-2-ylmethanone) (CAS: 617677-53-9)?

1,4-Piperazinediylbis(2,3-dihydro-1,4-benzodioxin-2-ylmethanone) is a white crystalline solid with a molecular weight of approximately 392.4 g/mol. It is sparingly soluble in water but soluble in common organic solvents like dichloromethane and acetonitrile. Chemically, it is stable under normal conditions but reacts with strong bases and acids. It is also photostable and resistant to hydrolysis.

How is 1,4-Piperazinediylbis(2,3-dihydro-1,4-benzodioxin-2-ylmethanone) (CAS: 617677-53-9) typically synthesized?

1,4-Piperazinediylbis(2,3-dihydro-1,4-benzodioxin-2-ylmethanone) is typically synthesized via a multi-step reaction involving the condensation of 2,3-dihydro-1,4-benzodioxin-2-ylmethanol with piperazine. The reaction is catalyzed by Lewis acids like aluminum chloride and proceeds with good yield. The synthetic route involves careful control of reaction conditions to ensure high selectivity and purity.

What industries use 1,4-Piperazinediylbis(2,3-dihydro-1,4-benzodioxin-2-ylmethanone) (CAS: 617677-53-9)?

1,4-Piperazinediylbis(2,3-dihydro-1,4-benzodioxin-2-ylmethanone) finds applications in the pharmaceutical industry as a precursor for drug synthesis, in the polymer industry for the development of advanced materials, and in sensor technology for the detection of various analytes. Additionally, it is used in semiconductor manufacturing for etching processes.

What precautions should be taken when handling 1,4-Piperazinediylbis(2,3-dihydro-1,4-benzodioxin-2-ylmethanone) (CAS: 617677-53-9)?

When handling 1,4-Piperazinediylbis(2,3-dihydro-1,4-benzodioxin-2-ylmethanone), it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated environment or fume hood. Spills should be cleaned up carefully using appropriate absorbents and disposed of according to local regulations. Refer to the Safety Data Sheet (SDS) for detailed handling and emergency procedures.

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