[2-(4-Methyl-2-phenyl-1-piperazinyl)-3-pyridinyl]methanol

Basic Information

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CAS Number

61337-89-1

Molecular Formula

C17H21N3O

Molecular Weight

283.38 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Melting Point

113-115°C

Boiling Point

478.8°C at 760 mmHg

SMILES

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CN1CCN(C(C1)C2=CC=CC=C2)C3=C(C=CC=N3)CO

InChI

InChI=1S/C17H21N3O/c1-19-10-11-20(17-15(13-21)8-5-9-18-17)16(12-19)14-6-3-2-4-7-14/h2-9,16,21H,10-13H2,1H3

InChIKey

PYZPABZGIRHQTA-UHFFFAOYSA-N

LogP

2.0669999999999997

Topological Polar Surface Area

39.6 Å²

Hydrogen Bond Donor/Acceptor

1 / 4

Complexity

319

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

AMY40875
PYZPABZGIRHQTA-UHFFFAOYSA-N
DIETHYL3,4-PYRROLEDICARBOXYLATE
2-(4-Methyl-2-phenylpiperazin-1-yl)pyridine-3-methanol
1-(3-hydroxymethyl pyridin-2-yl)-4-methyl-2-phenylpiperazine
F14603
FT-0640747
UNII-XRO2GE880O
A868737
DTXSID901036336
[2-[(2RS)-4-Methyl-2-phenyl-piperazin-1-yl]pyridin-3-yl]methanol; Mirtazapine Imp. B (EP); Mirtazapine Impurity B
1-(3-hydroxymethylpyridyl-2)-4-methyl-2-phenyl-piperazine
1-(3-hydroxymethyl pyridyl-2)-4-methyl-2-phenyl-piperazine
337376-18-8
EC 700-296-8
1-(3-hydroxidmethylpyridine)-2-phenyl-4-methyl-piperazine
A875208
SCHEMBL1325599
3-Pyridinemethanol, 2-(4-methyl-2-phenyl-1-piperazinyl)-
AC-23364
61337-89-1
1-(3-hydroxymethylpyridin-2-yl)-4-methyl-2-phenylpiperazine
ACYCLOMIRTAZAPINE ALCOHOL
DS-10746
CS-0313951
MFCD08063948
2-(4-Methyl-2-phenyl-1-piperazinyl)-3-pyridinemethanol
AC-15710
NS00009962
(2-(4-Methyl-2-phenylpiperazin-1-yl)pyridin-3-yl)methanol
1-(3-Hydroxymethyl pyridin-2-yl)-4-methyl-2-phenyl piperazine

MDL Number

MFCD08063948

Customs Code

2933990090

FAQ

What are the physical and chemical properties of [2-(4-Methyl-2-phenyl-1-piperazinyl)-3-pyridinyl]methanol (CAS: 61337-89-1)?

The compound [2-(4-Methyl-2-phenyl-1-piperazinyl)-3-pyridinyl]methanol (CAS: 61337-89-1) is a crystalline solid with a molecular weight of approximately 326.36 g/mol. It is slightly soluble in water but highly soluble in organic solvents like ethanol and chloroform. Chemically, it is relatively stable but can undergo hydrolysis in basic conditions. It is a potent ligand in coordination chemistry and finds applications in pharmaceuticals and materials science.

How is [2-(4-Methyl-2-phenyl-1-piperazinyl)-3-pyridinyl]methanol (CAS: 61337-89-1) typically synthesized?

The synthesis of [2-(4-Methyl-2-phenyl-1-piperazinyl)-3-pyridinyl]methanol (CAS: 61337-89-1) typically involves a multistep process, starting with the synthesis of 4-methyl-2-phenyl-1-piperazine, followed by its reaction with 3-pyridinecarbaldehyde. The key steps include condensation, reduction, and alcohol formation. Commonly, sodium borohydride is used as a reducing agent, and the reaction is conducted under acidic conditions to ensure high selectivity and yield.

What industries use [2-(4-Methyl-2-phenyl-1-piperazinyl)-3-pyridinyl]methanol (CAS: 61337-89-1)?

The compound [2-(4-Methyl-2-phenyl-1-piperazinyl)-3-pyridinyl]methanol (CAS: 61337-89-1) is primarily used in the pharmaceutical industry for its potential as an active pharmaceutical ingredient (API) due to its biological activity. It also has applications in the sensor industry, where its chemical reactivity is utilized, and in the semiconductor industry, where it can be used in the synthesis of certain materials.

What precautions should be taken when handling [2-(4-Methyl-2-phenyl-1-piperazinyl)-3-pyridinyl]methanol (CAS: 61337-89-1)?

When handling [2-(4-Methyl-2-phenyl-1-piperazinyl)-3-pyridinyl]methanol (CAS: 61337-89-1), it is essential to wear appropriate personal protective equipment (PPE), including gloves and safety glasses. Work should be conducted in a fume hood to minimize inhalation risks. Spills should be cleaned up using absorbent materials and disposed of according to local regulations. A Safety Data Sheet (SDS) should always be consulted for detailed safety information and emergency procedures.