1-(4-Chloro-3-hydroxyphenyl)ethanone

Basic Information

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CAS Number

61124-56-9

Molecular Formula

C8H7ClO2

Molecular Weight

170.6 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ketones

Fine Chemicals Dyes and Pigments Organic Dyes

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

106-107 ºC

Density

1.298±0.06 g/cm3 (20 ºC 760 Torr),

SMILES

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CC(=O)c1ccc(Cl)c(O)c1

InChI

InChI=1S/C8H7ClO2/c1-5(10)6-2-3-7(9)8(11)4-6/h2-4,11H,1H3

InChIKey

ZJRFCVYGGNITQR-UHFFFAOYSA-N

LogP

2.2482000000000006

Topological Polar Surface Area

37.3 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Synonyms & References

English

1-(4-Chloro-3-hydroxyphenyl)ethanone
Ethanone, 1-(4-chloro-3-hydroxyphenyl)-
1-(4-chloranyl-3-oxidanyl-phenyl)ethanone
1-(4-chloro-3-hydroxy-phenyl)-ethanone
3-Hydroxy-4-chloracetophenon
3-hydroxy-4-chloroacetophenone
4-chloro-3-hydroxyacetophenone
Ethanone,1-(4-chloro-3-hydroxyphenyl)

MDL Number

MFCD00034670

Customs Code

2914700090

FAQ

What are the physical and chemical properties of 1-(4-Chloro-3-hydroxyphenyl)ethanone (CAS: 61124-56-9)?

1-(4-Chloro-3-hydroxyphenyl)ethanone (CAS: 61124-56-9) is a crystalline solid with a molecular weight of 219.63 g/mol. It is poorly soluble in water but soluble in organic solvents like ethanol and acetone. Chemically, it is reactive towards bases, which can lead to hydrolysis. It is stable under normal conditions but should be stored in a dry place to prevent moisture absorption.

How is 1-(4-Chloro-3-hydroxyphenyl)ethanone (CAS: 61124-56-9) typically synthesized?

1-(4-Chloro-3-hydroxyphenyl)ethanone (CAS: 61124-56-9) is typically synthesized via an electrophilic aromatic substitution reaction. The reaction involves the chlorination of a phenolic compound followed by a condensation reaction. Commonly, the synthesis requires a Lewis acid catalyst such as aluminum chloride. The selectivity and yield can be controlled by adjusting the reaction conditions.

What industries use 1-(4-Chloro-3-hydroxyphenyl)ethanone (CAS: 61124-56-9)?

1-(4-Chloro-3-hydroxyphenyl)ethanone (CAS: 61124-56-9) is primarily used in the pharmaceutical industry for the synthesis of certain drugs. It is also utilized in the polymer industry for its potential to form polymers with unique properties. Additionally, it has applications in the sensor industry for its reactivity and stability.

What precautions should be taken when handling 1-(4-Chloro-3-hydroxyphenyl)ethanone (CAS: 61124-56-9)?

When handling 1-(4-Chloro-3-hydroxyphenyl)ethanone (CAS: 61124-56-9), it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. It should be handled in a well-ventilated area or a fume hood due to its potential to release harmful vapors. In case of a spill, immediately contain it and clean up using appropriate methods. Always consult the Safety Data Sheet (SDS) for detailed handling instructions and emergency procedures.