Tasimelteon | CAS No. 609799-22-6

Tasimelteon

Basic Information

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CAS Number

609799-22-6

Molecular Formula

C15H19NO2

Molecular Weight

245.32 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Melting Point

78°C

Boiling Point

442.6±24.0°C at 760 mmHg

Density

1.145

SMILES

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CCC(=O)NCC1CC1C2=C3CCOC3=CC=C2

InChI

InChI=1S/C15H19NO2/c1-2-15(17)16-9-10-8-13(10)11-4-3-5-14-12(11)6-7-18-14/h3-5,10,13H,2,6-9H2,1H3,(H,16,17)/t10-,13+/m0/s1

InChIKey

PTOIAAWZLUQTIO-GXFFZTMASA-N

LogP

2.2512

Topological Polar Surface Area

38.33 Å²

Hydrogen Bond Donor/Acceptor

1 / 3

Complexity

318

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

BMS-214,778
UNII-SHS4PU80D9
TASIMELTEON [VANDF]
BMS-214778
s4281
MFCD09033789
SHS4PU80D9
TASIMELTEON [WHO-DD]
T3813
VEC 162
Q7687250
BMS214778
HetliozLQ
PTOIAAWZLUQTIO-GXFFZTMASA-N
CCG-266915
Tasimelteon [USAN]
DB09071
TASIMELTEON [MI]
AC-6143
AKOS025149360
(trans)-N-[[2-(2,3-dihydrobenzofuran-4-yl)cyclopropyl]methyl]propanamide
(-)-(trans)-N-[[2-(2,3-Dihydrobenzofuran-4-yl)cycloprop-1-yl] methyl]propanamide
tasimelteonum
N-{[(1R,2R)-2-(2,3-dihydro-1-benzofuran-4-yl)cyclopropyl]methyl}propanamide
TASIMELTEON (MART.)
HY-14803
EN300-20605494
N-(((1R,2R)-2-(2,3-dihydrobenzofuran-4-yl)cyclopropyl)methyl)propionamide
VEC-162
Tasimelteon
BMS-214778;VEC-162

MDL Number

MFCD09033789

FAQ

What are the physical and chemical properties of Tasimelteon (CAS: 609799-22-6)?

Tasimelteon (CAS: 609799-22-6) is a melatonin receptor agonist. It is a white or pale yellow crystalline powder with a molecular weight of approximately 348.35 g/mol. The compound is slightly soluble in water and ethanol. It has a high chemical stability and is not reactive under normal conditions. Tasimelteon is primarily used in the treatment of circadian rhythm disorders, particularly in patients with non-24-hour sleep-wake disorder.

How is Tasimelteon (CAS: 609799-22-6) typically synthesized?

Tasimelteon (CAS: 609799-22-6) is synthesized through a multistep process involving several key reactions. The synthesis typically starts with a readily available starting material, such as 2-aminobenzaldehyde, which undergoes multiple functional group transformations. Common synthetic routes involve protective group strategies, selective aminomethylation, and catalytic hydrogenation. The final product is obtained with good to excellent yield, often requiring column chromatography for purification.

What industries use Tasimelteon (CAS: 609799-22-6)?

Tasimelteon (CAS: 609799-22-6) is primarily used in the pharmaceutical industry. It is approved by the FDA for the treatment of circadian rhythm sleep disorders, specifically non-24-hour sleep-wake disorder in blind individuals. While not directly used in other industries like polymers or sensors, its synthesis and use involve advancements in chemical and pharmaceutical sciences.

What precautions should be taken when handling Tasimelteon (CAS: 609799-22-6)?

When handling Tasimelteon (CAS: 609799-22-6), it is important to follow standard laboratory safety protocols. Wear appropriate personal protective equipment, including gloves and safety goggles. Work in a well-ventilated area or a fume hood to minimize exposure. Avoid contact with skin and eyes. In case of a spill, immediately clean up using appropriate methods and consult the Material Safety Data Sheet (MSDS) for further guidance. Ensure proper storage in a cool, dry place away from direct sunlight and moisture.