Apremilast Impurity 2

Basic Information

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CAS Number

608141-42-0

Molecular Formula

C12H19NO4S

Molecular Weight

273.35 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Density

1.195±0.06 g/cm3 (20 ºC 760 Torr),

SMILES

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CCOc1cc(ccc1OC)[C@@H](CS(=O)(=O)C)N

InChI

InChI=1S/C12H19NO4S/c1-4-17-12-7-9(5-6-11(12)16-2)10(13)8-18(3,14)15/h5-7,10H,4,8,13H2,1-3H3/t10-/m1/s1

InChIKey

BXUJVINGXQGNFD-SNVBAGLBSA-N

LogP

1.1382999999999999

Topological Polar Surface Area

78.62 Å²

Hydrogen Bond Donor/Acceptor

2 / 5

Complexity

339

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

(S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine
(1S)-1-(3-Ethoxy-4-methoxy-phenyl)-2-methanesulfonyl-ethylamine
(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethanamine
(ALPHAS)-3-ETHOXY-4-METHOXY-ALPHA-[(METHYLSULFONYL)METHYL]-BENZENEMETHANAMINE
(S)-1-(1-phenylethyl)urea
Benzenemethanamine, 3-ethoxy-4-methoxy-a-[(methylsulfonyl)methyl]-,(aS)-
Aprimilast Intermediate
(S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethylamine
(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethan-1-amine
C12H19NO4S
(S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethan-1-amine
BXUJVINGXQGNFD-SNVBAGLBSA-N
AK137359
Apremilast Intermediate II
BCP10023
DT1853
2841

MDL Number

MFCD22677268

FAQ

What is Apremilast Impurity 2 (CAS: 608141-42-0)?

Apremilast Impurity 2 is a by-product of the synthesis of apremilast, a phosphodiesterase 4 inhibitor used in the treatment of psoriasis and rheumatoid arthritis. Its chemical formula is not publicly disclosed due to proprietary reasons, but it is known to have similar molecular characteristics to the parent compound. It is characterized by low solubility and stability under various conditions.

What are the main uses of Apremilast Impurity 2 (CAS: 608141-42-0)?

Apremilast Impurity 2 is primarily used in quality control and impurity profiling during the development and production of apremilast. It helps in identifying and quantifying impurities to ensure product purity and efficacy.

Is Apremilast Impurity 2 (CAS: 608141-42-0) safe?

Apremilast Impurity 2 is considered safe under normal storage and handling conditions. It is important to follow safety guidelines, including proper ventilation, personal protective equipment, and avoidance of contact with eyes and skin. Toxicological data for the impurity is limited, but it is not considered a significant risk in pharmaceutical applications.

How should Apremilast Impurity 2 (CAS: 608141-42-0) be stored?

Apremilast Impurity 2 should be stored in a cool, dry place, preferably between 15-25°C (59-77°F) and away from direct sunlight. The container should be tightly sealed to prevent moisture and light exposure. It is recommended to store in a low humidity environment to maintain stability. Do not store in close proximity to incompatible substances.