Apremilast | CAS No. 608141-41-9

Apremilast

Basic Information

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CAS Number

608141-41-9

Molecular Formula

C22H24N2O7S

Molecular Weight

460.51 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Density

1.381

SMILES

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CCOc1cc(ccc1OC)[C@@H](CS(=O)(=O)C)N2C(=O)c3cccc(NC(=O)C)c3C2=O

InChI

InChI=1S/C22H24N2O7S/c1-5-31-19-11-14(9-10-18(19)30-3)17(12-32(4,28)29)24-21(26)15-7-6-8-16(23-13(2)25)20(15)22(24)27/h6-11,17H,5,12H2,1-4H3,(H,23,25)/t17-/m1/s1

InChIKey

IMOZEMNVLZVGJZ-QGZVFWFLSA-N

LogP

2.4342000000000006

Topological Polar Surface Area

119.07999999999998 Å²

Hydrogen Bond Donor/Acceptor

1 / 9

Complexity

825

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H317 May cause an allergic skin reaction
Sensitization, Skin

Synonyms & References

English

ApreMilast
(S)-N-(2-(1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide
ApreMilast,CC-10004
AcetaMide, N-[2-[(1S)-1-(3-ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-
Appleton West
(S)-N-(2-(1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide Apremilast (CC-10004
(S)-N-(2-(1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)
N-[2-[(1S)-1-(3ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamide
Apremilast QCR-202 CC10004
1,3-Dioxo-2-isoindolineaceticacid
Apremilast (CC-10004)
ApreMilast, (S)-2-[1-(3-Ethoxy-4-Methoxyphenyl)-2-Methylsulfonylethyl]-4-acetylaMinoisoindoline-1,3-dione
LCZ696
N-[2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-1,3-dioxoisoindol-4-yl]acetamide
(S)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione
CC10004
CC-10004
N-{2-[(1S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide
Unii-up7qbp99pn
Apremilast(CC-10004)
OTEZLA
CC 10004
apremilastum
UP7QBP99PN
C22H24N2O7S
Apremilast [USAN:INN]
Otezla (TN)
Apremilast (JAN/USAN)
Apremilast/CC 10004/
GTPL7372
QC

MDL Number

MFCD18782607

FAQ

What is Apremilast (CAS: 608141-41-9)?

Apremilast (CAS: 608141-41-9) is a selective phosphodiesterase-4 (PDE4) inhibitor with the chemical formula C19H23NO5S. It is a white to off-white crystalline solid, poorly soluble in water, and exhibits anti-inflammatory properties by modulating cytokine production. Apremilast is primarily used in pharmaceutical applications for treating inflammatory conditions.

What are the main uses of Apremilast (CAS: 608141-41-9)?

Apremilast (CAS: 608141-41-9) is mainly used as a medication for psoriatic arthritis and plaque psoriasis. It works by inhibiting PDE4 enzymes, reducing inflammation and immune response. Additionally, it is utilized in research for studying inflammatory diseases and as a tool compound in drug development.

Is Apremilast (CAS: 608141-41-9) safe?

Apremilast (CAS: 608141-41-9) is generally safe when used as prescribed, with a well-established safety profile in clinical settings. However, it may cause side effects such as gastrointestinal discomfort, headache, or nausea. Proper handling, including use of personal protective equipment, is recommended for laboratory settings. It is approved by regulatory agencies like the FDA for therapeutic use.

How should Apremilast (CAS: 608141-41-9) be stored?

Apremilast (CAS: 608141-41-9) should be stored in a cool, dry place, away from direct light, in a sealed container. It maintains stability at controlled room temperature (15-30°C) and is less sensitive to humidity. Always store in a secure location to prevent contamination or accidental exposure.