Bifonazole | CAS No. 60628-96-8

Bifonazole

Basic Information

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CAS Number

60628-96-8

Molecular Formula

C22H18N2

Molecular Weight

310.4 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Melting Point

147.0 to 151.0 deg-C

Boiling Point

491.7°C at 760 mmHg

Density

1.1150 (rough estimate)

Flash Point

251.2 oC

Solubility

Soluble in DMSO

Refractive Index

1.7620 (estimate)

SMILES

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c1ccc(cc1)c2ccc(cc2)C(c3ccccc3)n4ccnc4

InChI

InChI=1S/C22H18N2/c1-3-7-18(8-4-1)19-11-13-21(14-12-19)22(24-16-15-23-17-24)20-9-5-2-6-10-20/h1-17,22H

InChIKey

OCAPBUJLXMYKEJ-UHFFFAOYSA-N

LogP

5.187800000000005

Topological Polar Surface Area

17.82 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Complexity

362

Safety Information

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GHS Hazard Pictograms

H302

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

Toxicity

LD50 in male mice, rats (mg/kg): 2629, 2854 orally (Schlüter)

Synonyms & References

English

1[4,ALPHA-DIPHENYLBENZYL]-IMIDAZOLE
1-[P,ALPHA-DIPHENYLBENZYL]IMIDAZOLE
1-[phenyl-(4-phenylphenyl)-methyl]imidazole
BIFONAZOLE
mycospor
1-((1,1’-biphenyl)-4-ylphenylmethyl)-1h-imidazol
1-((4-biphenylyl)phenylmethyl)-1h-imidazole
1-(alpha-(4-biphenylyl)benzyl)-imidazol
1-(alpha-(4-biphenylyl)benzyl)imidazole
1-[(1,1’-biphenyl)-4-ylphenylmethyl]-1H-Imidazole
bayh4502
bifonazol
Biphenylylbenzylazole
trifonazole
1-(p,α-diphenylbenzyl)imidazole
BIFONAZOLE(PATENT-NOSUPPLY)
1-[α-(4-biphenyl)benzyl]-1H-imidazole
1H-Imidazole, 1-([1,1'-biphenyl]-4-ylphenylmethyl)-
Amycor
A-One-L
(±)-Bifonazole
1-[phenyl-(4-phenylphenyl)methyl]imidazole
(biphenyl-4-yl)phenyl-imidazol-1-ylmethane
1-(biphenyl-4-yl-phenyl-methyl)-1H-imidazole
Azolmen
Bifonazol [INN-Spanish]
Bifonazolum
rac-bifonazole
1-(α,4-Diphenylbenzyl)imidazole
1-(Biphenyl-4-yl(Phenyl)Methyl)-1H-Imidazole
BAY H 4502

MDL Number

MFCD00865567

Customs Code

2933290090

FAQ

What is Bifonazole (CAS: 60628-96-8)?

Bifonazole is an antifungal medication with the chemical formula C12H12Cl2N2O2. It belongs to the imidazole class of antifungal agents and is known for its broad-spectrum activity against fungi. Bifonazole is commonly used in topical formulations for treating fungal infections such as athlete's foot, ringworm, and jock itch. It works by inhibiting the synthesis of ergosterol, a key component of fungal cell membranes, thereby disrupting their growth and survival.

What are the main uses of Bifonazole (CAS: 60628-96-8)?

Bifonazole is primarily used in dermatology for treating fungal infections. It is available in various forms, including creams, lotions, and sprays, and is effective against dermatophytes, yeasts, and some molds. Its applications also extend to veterinary medicine for skin conditions in animals. Additionally, it is used in research for studying antifungal mechanisms and in industrial settings for the production of antifungal products.

Is Bifonazole (CAS: 60628-96-8) safe?

Bifonazole is generally considered safe when used as directed. It has low toxicity and is well-tolerated in topical applications. However, some individuals may experience skin irritation, redness, or itching. To ensure safety, follow the recommended dosage and avoid contact with eyes or mucous membranes. Ingestion should be avoided, and proper protective measures should be taken during handling to prevent accidental exposure.

How should Bifonazole (CAS: 60628-96-8) be stored?

Bifonazole should be stored in a cool, dry place away from direct sunlight. It is stable under normal storage conditions and typically has a shelf life of up to 2 years. Keep the container tightly closed to prevent moisture ingress and ensure the product remains effective. Store out of reach of children and avoid exposure to high temperatures or humidity to maintain its quality and potency.