Binimetinib | CAS No. 606143-89-9

Binimetinib

Basic Information

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CAS Number

606143-89-9

Molecular Formula

C17H15BrF2N4O3

Molecular Weight

441.23 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Density

1.67

SMILES

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CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)F)C(=O)NOCCO

InChI

InChI=1S/C17H15BrF2N4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26)

InChIKey

ACWZRVQXLIRSDF-UHFFFAOYSA-N

LogP

3.0113000000000016

Topological Polar Surface Area

88.41000000000001 Å²

Hydrogen Bond Donor/Acceptor

3 / 7

Complexity

521

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

1H-Benzimidazole-6-carboxamide, 5-[(4-bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-meth yl-
MEK162 (ARRY-162, ARRY-438162)
1H-Benzimidazole-6-carboxamide, 5-[(4-bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)...
1H-Benzimidazole-6-carboxamide,5-[(4-bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-
5-[(4-Bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide
6-(4-bromo-2-fluoroanilino)-7-fluoro-N-(2-hydroxyethoxy)-3-methylbenzimidazole-5-carboxamide
Binimetinib
Binimetinib (MEK-162)
Binimetinib (MEK-162, ARRY-162, ARRY-438162)
Binimetinib (MEK162, ARRY-162, ARRY-438162)
MEK 162
MK-1775
6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethoxy)amide
6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid-(2-hydroxyethyoxy)amide
ARRY 162
ARRY 438162
ARRY-162
ARRY-162,MEK-162
ARRY-438162
MEK-162
QCR-138
MEK162
181R97MR71
Binimetinib [USAN:INN]
Mektovi
Mektovi (TN)
MEK162(Binimetinib)
Binimetinib (JAN/USAN)
MLS006011180
C17H15BrF2N4O3
GTPL7921

MDL Number

MFCD22124525

FAQ

What regulatory guidelines apply to binimetinib (CAS: 606143-89-9)?

Binimetinib (CAS: 606143-89-9) falls under several regulatory guidelines. It must comply with REACH in Europe, which requires registration of substances above a certain tonnage. In the United States, it is regulated by the FDA for pharmaceutical uses and EPA for environmental safety. Additionally, it should adhere to GHS classification standards for chemical hazards.

Are there alternatives to binimetinib (CAS: 606143-89-9) in synthesis?

Binimetinib (CAS: 606143-89-9) has several analogs and isomers that can be used in synthesis. Common alternatives include other MEK inhibitors, such as trametinib and cobimetinib. Substitute reagents like different aldehydes or ketones can also be explored, depending on the specific synthetic route.

What is the market or research trend for binimetinib (CAS: 606143-89-9)?

Binimetinib (CAS: 606143-89-9) is a focus in oncology research, particularly for treating RAS-driven cancers. Market trends indicate increasing demand due to its effectiveness in combination therapies. Research is also exploring new applications and improving its delivery systems to enhance therapeutic outcomes.

How should waste containing binimetinib (CAS: 606143-89-9) be handled?

Waste containing binimetinib (CAS: 606143-89-9) should be handled with care to comply with environmental regulations. Collect waste liquids in appropriate containers and incinerate or dispose of them through a professional service. Ensure all handling procedures are documented and follow local, state, and federal guidelines for hazardous waste management.