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5-[(4-Bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide | CAS No. 606143-52-6

5-[(4-Bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide

Basic Information

Chemical_Structure_Of
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CAS Number

606143-52-6

Molecular Formula

C17H15BrClFN4O3

Molecular Weight

457.69 g/mol

AD

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids
Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds
Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates
Fine Chemicals Dyes and Pigments Organic Dyes
Fine Chemicals Surfactants Anionic Surfactants
Fine Chemicals Specialty Chemicals UV Stabilizers
Agricultural Chemicals Pesticides Herbicides
Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Melting Point

>219°C

Density

1.69

Refractive Index

1.672

SMILES

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CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)Cl)C(=O)NOCCO

InChI

InChI=1S/C17H15BrClFN4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26)

InChIKey

CYOHGALHFOKKQC-UHFFFAOYSA-N

LogP

3.525600000000002

Topological Polar Surface Area

88.41000000000001 Ų

Hydrogen Bond Donor/Acceptor

3 / 7

Complexity

523

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral
H315 Causes skin irritation
Skin corrosion/irritation
H319 Causes serious eye irritation
Serious eye damage/eye irritation
H332 Harmful if inhaled
Acute toxicity, inhalation
H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

  • 606143-52-6
  • 6-(4-bromo-2-chloroanilino)-7-fluoro-N-(2-hydroxyethoxy)-3-methylbenzimidazole-5-carboxamide
  • 6-(4-bromo-2-chlorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid(2-hydroxyethoxy)-amide
  • Selumetinib (USAN/INN)
  • AZD6244
  • HMS3654O03
  • 5-[(4-BROMO-2-CHLOROPHENYL)AMINO]-4-FLUORO-N-(2-HYDROXYETHOXY)-1-METHYL-1H-BENZIMIDAZOLE-6-CARBOXAMIDE
  • SELUMETINIB [WHO-DD]
  • 6-(4-Bromo-2-chloro-phenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxy-ethoxy)-amide
  • 1H-Benzimidazole-6-carboxamide, 5-((4-bromo-2-chlorophenyl)amino)-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-
  • BCP01739
  • UNII-6UH91I579U
  • SELUMETINIB [MI]
  • NS00071922
  • D09666
  • 6UH91I579U
  • Q-101405
  • BDBM50355497
  • MEK inhibitor AZD6244
  • ARRY-886
  • Koselugo
  • 5-((4-bromo-2-chlorophenyl)amino)-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzo[d]imidazole-6-carboxamide
  • AM808016
  • NSC 741O78
  • CAS-606143-52-6
  • NCGC00189073-01
  • 6-(4-bromo-2-chlorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethoxy)-amide
  • NCGC00189073-07
  • HY-50706
  • Selumetinib
  • selumetinibum

MDL Number

MFCD11977472

Customs Code

2934999090

FAQ

What is 5-[(4-Bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide (CAS: 606143-52-6)?
5-[(4-Bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide (CAS: 606143-52-6) is a complex organic compound containing a benzimidazole ring with multiple functional groups. Its structure includes bromo, chloro, fluoro, and hydroxyl substituents, making it a potential pharmaceutical intermediate. It is typically a solid at room temperature with moderate solubility in polar solvents.

What are the main uses of 5-[(4-Bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide (CAS: 606143-52-6)?
This compound is primarily used in pharmaceutical research for developing drugs targeting infectious diseases and cancer. Its unique structure enables interactions with biological systems, making it valuable in medicinal chemistry. It may also serve as a synthetic building block in organic chemistry applications and industrial processes requiring functional group modification.

Is 5-[(4-Bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide (CAS: 606143-52-6) safe?
Safety of this compound depends on handling conditions. It is generally considered toxic if ingested or inhaled, requiring protective measures like gloves, goggles, and ventilation. Proper disposal and adherence to OSHA guidelines are essential. Always consult safety data sheets (SDS) for specific risk assessments and protective recommendations.

How should 5-[(4-Bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide (CAS: 606143-52-6) be stored?
Store this compound in a cool, dry place (ideally 2-8°C), away from direct light, and in a sealed container to prevent moisture absorption. Maintain low humidity levels to ensure stability. Avoid exposure to air and incompatible substances to maintain chemical integrity and safety.

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Supplier Information

5-[(4-Bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide — Wuhan BoOutline Biotechnology Co., Ltd.

Wuhan BoOutline Biotechnology Co., Ltd.

CAS Number: 606143-52-6

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Shanghai Pinbo Real Estate Development Co., Ltd.

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AnZhouBeiErKa Biotechnology Co Ltd

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5-[(4-Bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide — SaiDaoTongShengWuKeJi （ ShangHai ） YouXianGongSi - AnZhouBanShiChu

SaiDaoTongShengWuKeJi （ ShangHai ） YouXianGongSi - AnZhouBanShiChu

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5-[(4-Bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide — MedChemExpress LLC

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