2-(Bromomethyl)-5-chloropyridine

Basic Information

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CAS Number

605681-01-4

Molecular Formula

C6H5BrClN

Molecular Weight

206.47 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Boiling Point

227 ºC

Density

1.663

Flash Point

91 ºC

SMILES

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Clc1ccc(CBr)nc1

InChI

InChI=1S/C6H5BrClN/c7-3-6-2-1-5(8)4-9-6/h1-2,4H,3H2

InChIKey

XRXRADIPZRXCQJ-UHFFFAOYSA-N

LogP

2.629900000000001

Topological Polar Surface Area

12.89 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Synonyms & References

English

2-(Bromomethyl)-5-chloropyridine
2-Bromomethyl-5-chloropyridine
Pyridine, 2-(bromomethyl)-5-chloro- (9CI)
5-chloro-2-bromomethylpyridine
AK109769
CTK8J5827
FT-0650555
KB-204575
pyridine,2-(bromomethyl)-5-chloro-
SureCN1495307

MDL Number

MFCD15526705

FAQ

What are the physical and chemical properties of 2-(Bromomethyl)-5-chloropyridine (CAS: 605681-01-4)?

2-(Bromomethyl)-5-chloropyridine (CAS: 605681-01-4) is a crystalline compound with a molecular weight of approximately 207.01 g/mol. It has a low water solubility and is moderately soluble in organic solvents like ethanol and acetone. The compound exhibits basic behavior due to the presence of the pyridine ring and can react with acids to form salts. It is stable under normal storage conditions but requires protection from moisture and direct sunlight.

How is 2-(Bromomethyl)-5-chloropyridine (CAS: 605681-01-4) typically synthesized?

2-(Bromomethyl)-5-chloropyridine (CAS: 605681-01-4) can be synthesized by bromomethylation of 5-chloropyridine. This process typically involves the reaction of 5-chloropyridine with bromine in the presence of a catalyst such as iron(III) bromide. The reaction is carried out under anhydrous conditions to minimize side reactions and improve yield. The product is obtained as a crystalline solid with a typical yield of around 80%.

What industries use 2-(Bromomethyl)-5-chloropyridine (CAS: 605681-01-4)?

2-(Bromomethyl)-5-chloropyridine (CAS: 605681-01-4) is used in the pharmaceutical industry for the synthesis of certain drugs. It also finds applications in the organic synthesis of functional materials, such as in the preparation of sensors and semiconductors. Additionally, this compound can be used as an intermediate in the development of new chemical entities (NCEs) for drug discovery processes.

What precautions should be taken when handling 2-(Bromomethyl)-5-chloropyridine (CAS: 605681-01-4)?

When handling 2-(Bromomethyl)-5-chloropyridine (CAS: 605681-01-4), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be handled using appropriate absorbents, and the area should be thoroughly cleaned. Always refer to the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.