2-(Bromomethyl)-5-chloropyridine(CAS: 605681-01-4)

2-(Bromomethyl)-5-chloropyridine (CAS: 605681-01-4) is a crystalline compound with a molecular weight of approximately 207.01 g/mol. It has a low water solubility and is moderately soluble in organic solvents like ethanol and acetone. The compound exhibits basic behavior due to the presence of the pyridine ring and can react with acids to form salts. It is stable under normal storage conditions but requires protection from moisture and direct sunlight.

2-(Bromomethyl)-5-chloropyridine (CAS: 605681-01-4) can be synthesized by bromomethylation of 5-chloropyridine. This process typically involves the reaction of 5-chloropyridine with bromine in the presence of a catalyst such as iron(III) bromide. The reaction is carried out under anhydrous conditions to minimize side reactions and improve yield. The product is obtained as a crystalline solid with a typical yield of around 80%.

2-(Bromomethyl)-5-chloropyridine (CAS: 605681-01-4) is used in the pharmaceutical industry for the synthesis of certain drugs. It also finds applications in the organic synthesis of functional materials, such as in the preparation of sensors and semiconductors. Additionally, this compound can be used as an intermediate in the development of new chemical entities (NCEs) for drug discovery processes.

When handling 2-(Bromomethyl)-5-chloropyridine (CAS: 605681-01-4), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be handled using appropriate absorbents, and the area should be thoroughly cleaned. Always refer to the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.