N,N-Dimethyl-1-(10H-phenothiazin-10-yl)-2-propanamine

Basic Information

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CAS Number

60-87-7

Molecular Formula

C17H20N2S

Molecular Weight

284.43 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Melting Point

60 ºC

Boiling Point

bp3 190-192°

Density

1.131

Refractive Index

1.6000 (estimate)

SMILES

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CC(CN1c2ccccc2Sc3c1cccc3)N(C)C

InChI

InChI=1S/C17H20N2S/c1-13(18(2)3)12-19-14-8-4-6-10-16(14)20-17-11-7-5-9-15(17)19/h4-11,13H,12H2,1-3H3

InChIKey

PWWVAXIEGOYWEE-UHFFFAOYSA-N

LogP

4.239400000000004

Topological Polar Surface Area

6.48 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Complexity

298

Synonyms & References

English

10H-Phenothiazine-10-ethanamine,N,N,a-trimethyl-
promethazine
(RS)-dimethyl[1-methyl-2-(phenothiazone-10-yl)ethyl]amine hydrochloride
10-[2-(dimethylamino)propyl]phenothiazine
3277 RP
Aprobit
Avomine
Dimapp
EP STANDARD
Fargan
Fenazil
Procit
PROMETHAZINE IMPURITY D (2RS)-N,N-DIMETHYL-1-(10H-PHENOTHIAZIN-10-YL)PROPAN-2-AMINE S-OXIDE
Prorex
WY 509
Prometazin
Protazine
Prothazin
RP 3277
Vallergine
(2-Dimethylamino-2-methyl)ethyl-N-dibenzoparathiazine
dimethyl1-(10H-phenothiazin-10-yl)propan-2-ylamine

MDL Number

MFCD00066294

Customs Code

2934300000

FAQ

What are the physical and chemical properties of N,N-Dimethyl-1-(10H-phenothiazin-10-yl)-2-propanamine (CAS: 60-87-7)?

N,N-Dimethyl-1-(10H-phenothiazin-10-yl)-2-propanamine is a crystalline solid at room temperature. It has a molecular weight of approximately 286.33 g/mol. This compound is slightly soluble in water and more soluble in organic solvents like ethanol and acetone. It is a moderately reactive compound, showing basic properties due to its amine group. It can react with acids to form salts and with alkylating agents to form alkylated products.

How is N,N-Dimethyl-1-(10H-phenothiazin-10-yl)-2-propanamine (CAS: 60-87-7) typically synthesized?

N,N-Dimethyl-1-(10H-phenothiazin-10-yl)-2-propanamine is typically synthesized through a multi-step process involving the condensation of 10-hydroxyphenothiazine with dimethylamine followed by alkyl substitution. This synthesis involves the use of a base like sodium hydride and organic solvents. The yield and selectivity of this synthesis can be improved by optimizing reaction conditions such as temperature and stirring rate.

What industries use N,N-Dimethyl-1-(10H-phenothiazin-10-yl)-2-propanamine (CAS: 60-87-7)?

N,N-Dimethyl-1-(10H-phenothiazin-10-yl)-2-propanamine is used in the pharmaceutical industry for the development of antipsychotic drugs due to its phenothiazine moiety. It is also utilized in the polymer industry for improving the properties of certain polymers and in the sensor industry for its potential in detecting specific analytes. Its applications in semiconductor technology are currently under investigation.

What precautions should be taken when handling N,N-Dimethyl-1-(10H-phenothiazin-10-yl)-2-propanamine (CAS: 60-87-7)?

When handling N,N-Dimethyl-1-(10H-phenothiazin-10-yl)-2-propanamine, it is important to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be carried out in a well-ventilated area or fume hood. Spills should be handled with care, using appropriate absorbent materials and disposing of them according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed information on handling and disposal.