Cyclopropyl(1-piperazinyl)methanone

Basic Information

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CAS Number

59878-57-8

Molecular Formula

C8H14N2O

Molecular Weight

154.21 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Boiling Point

120 °C/0.15 mmHg

Density

1.087 g/mL at 25 °C

Refractive Index

n20/D 1.524

SMILES

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O=C(C1CC1)N2CCNCC2

InChI

InChI=1S/C8H14N2O/c11-8(7-1-2-7)10-5-3-9-4-6-10/h7,9H,1-6H2

InChIKey

KIALFUYSJAAJSU-UHFFFAOYSA-N

LogP

-0.17179999999999995

Topological Polar Surface Area

32.34 Å²

Hydrogen Bond Donor/Acceptor

1 / 3

Complexity

160

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H318 Causes serious eye damage
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

Cyclopropyl(piperazin-1-yl)methanone
1-(Cyclopropylcarbonyl)piperazine
1-(Cyclopropanecarbonyl)piperazine
1-(CYCLOPROPANECARBONYL)PIPERAZINE 97
1-(CYCLOPROPYLCARBONYL)PIPERAZINE HYDROCHLORIDE
N-(Cyclopropylcarbonyl)piperazine
1-cyclopropanecarbonylpiperazine
Cyclopropyl-piperazin-1-yl-methanone
1-cyclopropylcarbonylpiperazine
Piperazine, 1-(cyclopropylcarbonyl)-
Piperazinocyclopropyl ketone
cyclopropyl piperazinyl ketone
4-cyclopropanecarbonyl-piperazine
Cyclopro

MDL Number

MFCD06369645

FAQ

What are the physical and chemical properties of Cyclopropyl(1-piperazinyl)methanone (CAS: 59878-57-8)?

Cyclopropyl(1-piperazinyl)methanone (CAS: 59878-57-8) is a crystalline compound with a molecular weight of approximately 170.29 g/mol. It has a low solubility in water but is soluble in organic solvents such as ethanol and acetone. Physically, it is a colorless to white solid. Chemically, it is relatively stable under normal conditions but can react with strong acids or bases. It is also susceptible to degradation under high temperatures or prolonged exposure to light.

How is Cyclopropyl(1-piperazinyl)methanone (CAS: 59878-57-8) typically synthesized?

Cyclopropyl(1-piperazinyl)methanone (CAS: 59878-57-8) is typically synthesized via the reaction of cyclopropylmethanol with 1-piperazinecarboxaldehyde under basic conditions. This process involves the condensation of the aldehyde with the alcohol, followed by the cyclization to form the methanone structure. The reaction is usually catalyzed by an alkali such as sodium hydroxide, and the yield is typically around 60-70%.

What industries use Cyclopropyl(1-piperazinyl)methanone (CAS: 59878-57-8)?

Cyclopropyl(1-piperazinyl)methanone (CAS: 59878-57-8) is used in the pharmaceutical and polymer industries. In pharmaceuticals, it serves as a precursor to drug intermediates. In polymers, it can be used as a monomer or a crosslinking agent. Additionally, it finds application in the synthesis of certain sensors and semiconductors due to its unique chemical properties.

What precautions should be taken when handling Cyclopropyl(1-piperazinyl)methanone (CAS: 59878-57-8)?

When handling Cyclopropyl(1-piperazinyl)methanone (CAS: 59878-57-8), it is important to wear appropriate personal protective equipment (PPE), including gloves and safety glasses. This compound should be handled in a well-ventilated area or a fume hood to minimize exposure to vapors. Spills should be cleaned up carefully using absorbent materials, and the area should be flushed with water. Always consult the Safety Data Sheet (SDS) for detailed safety information and guidelines.