Dihydro Cyclosporin A

Basic Information

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CAS Number

59865-15-5

Molecular Formula

C62H113N11O12

Molecular Weight

1204.65 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Surfactants Anionic Surfactants

Polymers and Plastics Thermoplastics Polyolefins

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Melting Point

120-125?C

Density

1.012±0.06 g/cm3 (20 ºC 760 Torr),

SMILES

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CCCC[C@@H](C)[C@H]([C@H]1C(=O)N[C@H](C(=O)N(CC(=O)N([C@H](C(=O)N[C@H](C(=O)N([C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N1C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C)CC)O

InChI

InChI=1S/C62H113N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h34-47,49-52,75H,25-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/t40-,41+,42-,43+,44+,45+,46+,47+,49+,50+,51+,52-/m1/s1

InChIKey

TYFOVYYNQGNDKH-HHPJSCBPSA-N

LogP

3.4930000000000043

Topological Polar Surface Area

278.8 Å²

Hydrogen Bond Donor/Acceptor

5 / 23

Synonyms & References

English

Cyclosporin A,6-[(2S,3R,4R)-3-hydroxy-4-methyl-2-(methylamino)octanoic acid]-
Dihydro Cyclosporin A
(3R,4R)-3-Hydroxy-4,N-dimethyl-5-propylcyclo[L-Nva-L-Abu-Sar-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-L-Ala-D-Ala-N-methyl-L-Leu-N-methyl-L-Leu-N-methyl-L-Val-]
(3R,4R)-3-Hydroxy-N-methyl-5-propylcyclo(L-Leu-L-Abu-Sar-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-L-Ala-D-Ala-N-methyl-L-Leu-N-methyl-L-Leu
<DH-MeBmt>cyclosporin
6-[(2S,3R,4R)-3-Hydroxy-4-Methyl-2-(MethylaMino)octanoic acid]cyclosporin A
dihydro-CSA
Dihydrocyclosporin
(3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-((1R,2R)-1-hydroxy-2-methylhexyl)-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecaone

MDL Number

MFCD08458303

FAQ

What is Dihydro Cyclosporin A (CAS: 59865-15-5)?

Dihydro Cyclosporin A (CAS: 59865-15-5) is a naturally occurring fungal metabolite that is a derivative of the immunosuppressive drug cyclosporine A. It contains the chemical formula C31H47NO11. Dihydro Cyclosporin A is known for its immunosuppressive properties and is used in research and potential therapeutic applications.

What are the main uses of Dihydro Cyclosporin A (CAS: 59865-15-5)?

Dihydro Cyclosporin A (CAS: 59865-15-5) is primarily used in research and clinical trials for its immunosuppressive properties. It is also being explored for its potential therapeutic uses in autoimmune diseases and organ transplantation. Additionally, it can be used in vitro to study immune cell function.

Is Dihydro Cyclosporin A (CAS: 59865-15-5) safe?

Dihydro Cyclosporin A (CAS: 59865-15-5) is generally safe when used under controlled conditions, but it can have toxic effects if not handled properly. It is important to follow all safety guidelines, including proper handling, storage, and disposal to prevent exposure and ensure safety.

How should Dihydro Cyclosporin A (CAS: 59865-15-5) be stored?

Dihydro Cyclosporin A (CAS: 59865-15-5) should be stored in a cool, dry place away from direct sunlight and heat sources. It should be kept in a tightly sealed container to protect it from moisture and light. Avoid storing it in humid or high-temperature environments, as this can degrade the compound. It should be stored at room temperature (15-30°C) and protected from light exposure to maintain its stability.