Ethyl 4-piperidinylacetate

Basic Information

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CAS Number

59184-90-6

Molecular Formula

C9H17NO2

Molecular Weight

171.24 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Physical State

Pale-yellow to Yellow-brown Liquid

Boiling Point

232.8°C at 760 mmHg

Flash Point

94.6℃

SMILES

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CCOC(=O)CC1CCNCC1

InChI

InChI=1S/C9H17NO2/c1-2-12-9(11)7-8-3-5-10-6-4-8/h8,10H,2-7H2,1H3

InChIKey

IHSUFLCKRIHFGY-UHFFFAOYSA-N

LogP

0.9392

Topological Polar Surface Area

38.33 Å²

Hydrogen Bond Donor/Acceptor

1 / 3

Complexity

142

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H332 Harmful if inhaled
Acute toxicity, inhalation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

ethyl 2-piperidin-4-ylacetate
2-(4-piperidinyl)acetic acid ethyl ester
Q-102143
2-(piperdin-4-yl)-acetic acid ethyl ester
Ethyl 2-(4-piperidyl)acetate
CS-W002927
ethyl-4-piperidinylacetate
ethyl piperidine-4-acetate
4-piperidine acetic acid ethyl ester
SY003777
FT-0647382
EN300-30459
ethyl 4-piperidineacetate
Ethyl (piperidin-4-yl)acetate
AKOS005072739
4-piperidineacetic acid ethyl ester
PB32303
ethyl 2-(piperidin-4-yl)acetate
4-Piperidineacetic acid, ethyl ester
SCHEMBL40428
AC-6484
Ethyl piperidin-4-yl-acetate
MFCD02183575
Ethyl 4-piperidylacetate
ethyl 2-(4-piperidinyl)acetate
IHSUFLCKRIHFGY-UHFFFAOYSA-N
FA-0865
AM20100441
2-(piperidin-4-yl)-acetic acid ethyl ester, AldrichCPR
ethyl piperidin-4-ylacetate
BCP21780

MDL Number

MFCD02183575

Customs Code

2933399090

FAQ

What are the physical and chemical properties of Ethyl 4-piperidinylacetate (CAS: 59184-96-2)?

Ethyl 4-piperidinylacetate (CAS: 59184-96-2) is a white crystalline solid at room temperature. Its molecular weight is approximately 170.26 g/mol. It is slightly soluble in water but more soluble in organic solvents like ethanol. It is reactive towards strong bases and acids. Its pKa is around 10. It is stable under normal conditions but should be stored in a cool, dry place to avoid degradation.

How is Ethyl 4-piperidinylacetate (CAS: 59184-96-2) typically synthesized?

Ethyl 4-piperidinylacetate (CAS: 59184-96-2) is typically synthesized via the condensation of 4-piperidinecarboxylic acid and ethyl chloroacetate in the presence of a base like sodium hydroxide. The reaction is carried out in an organic solvent like dichloromethane, and the product is isolated by recrystallization. The yield is around 75-85%, and the method provides a good level of selectivity.

What industries use Ethyl 4-piperidinylacetate (CAS: 59184-96-2)?

Ethyl 4-piperidinylacetate (CAS: 59184-96-2) is used in the pharmaceutical industry as a precursor for the synthesis of various compounds. It also finds application in the fragrance and flavor industry due to its pleasant odor. Additionally, it is used in the polymer industry to improve the properties of certain polymers.

What precautions should be taken when handling Ethyl 4-piperidinylacetate (CAS: 59184-96-2)?

Ethyl 4-piperidinylacetate (CAS: 59184-96-2) should be handled with care due to its reactivity. Wear appropriate personal protective equipment (PPE) such as gloves and goggles. It should be stored in a cool, dry place away from strong acids and bases. In case of spill, use appropriate spill kits and follow the safety data sheet (SDS) guidelines. Always work under a fume hood to avoid inhalation of vapors.