L-DOPA | CAS No. 59-92-7

L-DOPA

Basic Information

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CAS Number

59-92-7

Molecular Formula

C9H11NO4

Molecular Weight

197.19 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Physical State

Powder

Melting Point

276-278 °C

Boiling Point

448.4±45.0°C at 760 mmHg

Water Solubility

Slightly soluble in water, dilute hydrochloric acid and formic acid. Insoluble in ethanol.

Flash Point

225 °C

Solubility

5mM

Refractive Index

-12 ° (C=5, 1mol/L HCl)

Odor

Odorless

Specific Rotation

-11.7 º (c=5.3, 1N HCl)

SMILES

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N[C@@H](Cc1ccc(O)c(O)c1)C(=O)O

InChI

InChI=1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)/t6-/m0/s1

InChIKey

WTDRDQBEARUVNC-LURJTMIESA-N

LogP

0.052200000000000135

pKa

2.32(at 25℃)

Topological Polar Surface Area

103.78000000000002 Å²

Hydrogen Bond Donor/Acceptor

5 / 5

Complexity

209

Safety Information

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GHS Hazard Pictograms

H302

H315

H319

H335

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Storage Conditions

2-8℃

Stability

Stable. Incompatible with strong oxidizing agents. Light and air sensitive.

Sensitiveness

Sensitive to light and air

Toxicity

LD50 in mice (mg/kg): 3650 ±327 orally, 1140 ±66 i.p., 450 ±42 i.v., >400 s.c.; in male, female rats (mg/kg): >3000, >3000 orally; 624, 663 i.p.; >1500, >1500 s.c. (Clark)

Synonyms & References

English

L-DOPA
L-3-(3,4-Dihydroxyphenyl)alanine
Levodopa
L-DOPA 3,4-L-Dihydroxyphenylalanine
3-Hydroxy-L-tyrosine
H-Tyr(3-OH)-OH
L-3-Hydroxytyrosine
3,4-Dihydroxy-L-phenylalanine
3-(3,4-Dihydroxyphenyl)-L-alanine
DOPA, L-(P)
L-3,4-Dihydrophenylalanine
2-AMino-3(3,4-dihydroxyphenyl)propanoic acid
3,4-Dihydroxyphenylalanine
Beldopa
Bendopa
Dopar
Doparl
Doprin
L-3-(3,4-Dihydroxyphenyl)alanine(L-DOPA )
L-3,4-dihydroxyphenylalanine
l-dop
Ledopa
Levodopa,L-DOPA
Levopa
Parda
Larodopa
Insulamina
Cidandopa
Maipedopa
Eldopal
Dopasol

MDL Number

MFCD00002598

Customs Code

2932999099

FAQ

What is L-DOPA (CAS: 59-92-7)?

L-DOPA (C9H11NO4) is a naturally occurring amino acid and precursor to dopamine, a neurotransmitter critical for motor control. It is used in the body to synthesize neurotransmitters and is also a key compound in pharmaceutical applications. L-DOPA is typically a white crystalline powder, soluble in water, and has a molecular weight of 197.19 g/mol. Its chemical structure includes a catechol group and a hydroxyl group, making it bioactive and essential in treating neurological disorders like Parkinson’s disease.

What are the main uses of L-DOPA (CAS: 59-92-7)?

L-DOPA (CAS: 59-92-7) is primarily used in pharmaceuticals to treat Parkinson’s disease by replenishing dopamine levels in the brain. It also serves as a research tool in neuroscience and neurochemistry studies. In industrial applications, it is used to synthesize other compounds, including drugs and pesticides. Additionally, L-DOPA is a dietary supplement in some contexts and plays a role in animal feed formulations. Its versatility makes it a key component in multiple fields.

Is L-DOPA (CAS: 59-92-7) safe?

L-DOPA (CAS: 59-92-7) is generally safe when used as prescribed, but it may cause side effects like nausea, vomiting, or dyskinesia. It is not considered toxic in standard handling, but proper precautions are necessary to avoid contamination. Safety standards emphasize controlled administration under medical supervision. When working with L-DOPA, wear protective gloves and eyewear to minimize exposure. Always follow guidelines for handling and disposal to ensure safety.

How should L-DOPA (CAS: 59-92-7) be stored?

L-DOPA (CAS: 59-92-7) should be stored in a cool, dry place, away from light, in a sealed container to prevent moisture ingress. Maintain storage temperature between 15-25°C and ensure humidity levels are low to preserve stability. Avoid exposure to air and heat to prevent degradation. Proper storage is crucial for maintaining its potency and safety. Always check manufacturer instructions for specific conditions.