8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine | CAS No. 5786-21-0

8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine

Basic Information

CAS Number

5786-21-0

Molecular Formula

C18H19ClN4

Molecular Weight

326.83 g/mol

AD

Basic Physical Properties

Melting Point

183.0 to 187.0 deg-C

Boiling Point

482.71°C (rough estimate)

Flash Point

9℃

Solubility

ethanol: 1 mg/mL

Refractive Index

1.6110 (estimate)

CN1CCN(CC1)C2=NC3=C(C=CC(=C3)Cl)NC4=CC=CC=C42

InChI

InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3

InChIKey

QZUDBNBUXVUHMW-UHFFFAOYSA-N

LogP

3.7227000000000023

pKa

3.70, 7.60(at 25℃)

Topological Polar Surface Area

30.869999999999997 Ų

Hydrogen Bond Donor/Acceptor

1 / 4

Complexity

446

Safety Information

View Safety Information

Hazard Statement

H301 Toxic if swallowed
Acute toxicity, oral
H341 Suspected of causing genetic defects
Germ cell mutagenicity
H361 Suspected of damaging fertility or the unborn child
Reproductive toxicity

Hazard Class

Class 6.1 Class 6.1

Toxicity

LD50 in mice, rats (mg/kg): 61, 58 i.v.; 199, 260 orally (Lindt)

Synonyms & References

English

  • SW220247-1
  • DTXSID401020663
  • NSC757429
  • 8-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine(Ciozapine)
  • C06924
  • CLOZAPINE [ORANGE BOOK]
  • Spectrum3_001828
  • CLOZAPINE [EP MONOGRAPH]
  • Clozapine (JAN/USP/INN)
  • Fazaclo ODT
  • Lepotex
  • HMS3402P12
  • AB00052158-14
  • DivK1c_000343
  • CLOZAPINE [HSDB]
  • EINECS 227-313-7
  • HMS3266A10
  • AKOS026749900
  • Clozapine for peak identification
  • HMS2092I16
  • Clozapine (teva)
  • KBio2_000599
  • HMS1569E21
  • HMS3371H05
  • AKOS005064444
  • Azaleptine
  • NCGC00015254-12
  • BC164328
  • Clozapine - Bio-X
  • NCGC00015254-11
  • Clozapinum (INN-Latin)

MDL Number

MFCD00153785

Customs Code

2933990090

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