4-Quinolinamine

Basic Information

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CAS Number

578-68-7

Molecular Formula

C9H8N2

Molecular Weight

144.18 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Melting Point

151.0 and le 155.0 deg-C

Boiling Point

332.3°C at 760 mmHg

Flash Point

181.2 °C

Refractive Index

1.7080 (estimate)

SMILES

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C1=CC=C2C(=C1)C(=CC=N2)N

InChI

InChI=1S/C9H8N2/c10-8-5-6-11-9-4-2-1-3-7(8)9/h1-6H,(H2,10,11)

InChIKey

FQYRLEXKXQRZDH-UHFFFAOYSA-N

LogP

1.817

pKa

9.17(at 20℃)

Topological Polar Surface Area

38.91 Å²

Hydrogen Bond Donor/Acceptor

2 / 2

Complexity

136

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Synonyms & References

English

4-Aminoquinoline
FT-0645211
EN300-37247
AM20061339
AC-1256
PS-3999
4-quinolylamine
AKOS000482611
Quinoline, 4-amino-
1LM
AB06141
MFCD00463448
NCGC00342714-01
CCRIS 1679
DTXSID70206491
SCHEMBL278276
139266-00-5
J-524176
AB4073
4-quinolinylamine
AE-848/32807060
4-aminoquinoline, AldrichCPR
4-Quinolinamine
quinolin-4-amine
UNII-GTE5P5L97N
4-amino quinoline
4-Aminoquinoline 7
AB00994061-03
4(1H)-Quinolinimine(9CI)
CS-W004931
4-AMINOQUINOLINE [VANDF]

MDL Number

MFCD00463448

Customs Code

2933499090

FAQ

What are the physical and chemical properties of 4-Quinolinamine (CAS: 578-68-7)?

4-Quinolinamine (CAS: 578-68-7) is a white crystalline solid with a molecular weight of 159.17 g/mol. It has a pKa of 10.1 and is very soluble in water (12.6 g/100 mL at 25°C). It is slightly soluble in ethanol and almost insoluble in benzenes. The compound is moderately reactive and can undergo substitution reactions.

How is 4-Quinolinamine (CAS: 578-68-7) typically synthesized?

4-Quinolinamine can be synthesized by various methods, including reduction of 4-quinolinecarboxylic acid with hydrogen in the presence of a catalyst like palladium on carbon. Another common method involves the condensation of 4-quinolone with ammonia or an amine compound. The yield and selectivity can vary depending on the chosen method.

What industries use 4-Quinolinamine (CAS: 578-68-7)?

4-Quinolinamine (CAS: 578-68-7) is primarily used in the pharmaceutical industry as a precursor for the synthesis of various bioactive compounds. It is also utilized in the production of dyes, sensors, and semiconductor materials. The compound's unique properties make it valuable in these applications.

What precautions should be taken when handling 4-Quinolinamine (CAS: 578-68-7)?

When handling 4-Quinolinamine (CAS: 578-68-7), it is important to use proper personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be stored in a well-ventilated area and handled in a fume hood to minimize inhalation risks. In case of a spill, immediately clean up the area and consult the safety data sheet (SDS) for further instructions.