1-Methoxy-2-methylbenzene

Basic Information

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CAS Number

578-58-5

Molecular Formula

C8H10O

Molecular Weight

122.17 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Physical Properties

Melting Point

-34.1°C

Boiling Point

171°C

Solubility

Chloroform, Ethyl Acetate (Slightly)

Refractive Index

n20/D 1.516(lit.)

SMILES

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COc1ccccc1C

InChI

InChI=1S/C8H10O/c1-7-5-3-4-6-8(7)9-2/h3-6H,1-2H3

InChIKey

DTFKRVXLBCAIOZ-UHFFFAOYSA-N

LogP

2.0036199999999997

Topological Polar Surface Area

9.23 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

80.6

Safety Information

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GHS Hazard Pictograms

H226

Hazard Statement

H226 Flammable liquid and vapor
Flammable liquids

Hazard Class

Class 3 Class 3

Synonyms & References

English

1-Methoxy-2-methylbenzene
2-METHOXYTOLUENE
FEMA 2680
METHYL O-TOLYL ETHER
O-CRESOL METHYL ETHER
O-METHYLANISOLE
1-methoxy-2-methyl-benzen
2-Methylanisol
2-Methylmethoxybenzene
Anisole, o-methyl-
Methyl o-cresyl ether
Methyl o-methylphenyl ether
o-Cresyl methyl ether
o-Methoxytoluene
o-Methylanisol
o-Cresyl methyl ether~2-Methoxytoluene
2-methylanisole,1-methoxy-3-methyl-benzene,o-methylanisole,o-methoxytoluene
2-Methylanisole
BENZENE, 1-METHOXY-2-METHYL-
Methyl-o-cresol
1-methoxy-2-methyl-benzene
Anisole, o-methyl- (8CI)
DTFKRVXLBCAIOZ-UHFFFAOYSA-N
09G73SL17K
Methoxytoluene, o-
met
o-Cresol Methyl Ether

MDL Number

MFCD00008373

Customs Code

29093090

FAQ

What are the physical and chemical properties of 1-Methoxy-2-methylbenzene (CAS: 578-58-5)?

1-Methoxy-2-methylbenzene (CAS: 578-58-5) is a colorless liquid with a molecular weight of approximately 144.19 g/mol. It has a low solubility in water but is more soluble in organic solvents like ethanol and acetone. Chemically, it is relatively stable but can undergo electrophilic aromatic substitution reactions.

How is 1-Methoxy-2-methylbenzene (CAS: 578-58-5) typically synthesized?

1-Methoxy-2-methylbenzene can be synthesized through a Friedel-Crafts alkylation reaction where toluene reacts with methanol in the presence of a sulfuric acid catalyst. The yield is generally good, and the reaction is selective for the 2-methyl position, yielding the desired product with high purity.

What industries use 1-Methoxy-2-methylbenzene (CAS: 578-58-5)?

1-Methoxy-2-methylbenzene (CAS: 578-58-5) is used in the pharmaceutical industry for the synthesis of certain drug molecules. It also finds applications in the production of polymers, particularly in the development of certain plasticizers and resins. Additionally, it is utilized in the manufacturing of chemical sensors and semiconductors.

What precautions should be taken when handling 1-Methoxy-2-methylbenzene (CAS: 578-58-5)?

When handling 1-Methoxy-2-methylbenzene (CAS: 578-58-5), it is essential to use appropriate personal protective equipment (PPE) such as gloves and eye protection. The substance should be stored in a well-ventilated area and handled using fume hoods to minimize exposure. In case of a spill, it is recommended to use appropriate spill cleanup kits and consult the Safety Data Sheet (SDS) for detailed instructions.