Compound Q&A

How is 1-Methoxy-2-methylbenzene (CAS: 578-58-5) typically synthesized?

Answer

1-Methoxy-2-methylbenzene
1-Methoxy-2-methylbenzene can be synthesized through a Friedel-Crafts alkylation reaction where toluene reacts with methanol in the presence of a sulfuric acid catalyst. The yield is generally good, and the reaction is selective for the 2-methyl position, yielding the desired product with high purity.

About

CAS No 578-58-5
English Name 1-Methoxy-2-methylbenzene
Molecular Formula C8H10O
Molecular Weight 122.17 g/mol
SMILES COc1ccccc1C
InChIKey DTFKRVXLBCAIOZ-UHFFFAOYSA-N
Last Updated: 2025-09-08 00:42

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