5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-tryptophyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide | CAS No. 57773-65-6

5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-tryptophyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide

Basic Information

CAS Number

57773-65-6

Molecular Formula

C64H83N17O12

Molecular Weight

1282.48 g/mol

AD

Basic Physical Properties

Specific Rotation

D24 -61° (c = 0.37 in 0.1M acetic acid)

CCNC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)C(CC2=CNC3=CC=CC=C32)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(CO)NC(=O)C(CC5=CNC6=CC=CC=C65)NC(=O)C(CC7=CN=CN7)NC(=O)C8CCC(=O)N8

InChI

InChI=1S/C64H83N17O12/c1-4-68-62(92)53-16-10-24-81(53)63(93)46(15-9-23-69-64(65)66)74-56(86)47(25-35(2)3)75-58(88)49(27-37-30-70-43-13-7-5-11-41(37)43)77-57(87)48(26-36-17-19-40(83)20-18-36)76-61(91)52(33-82)80-59(89)50(28-38-31-71-44-14-8-6-12-42(38)44)78-60(90)51(29-39-32-67-34-72-39)79-55(85)45-21-22-54(84)73-45/h5-8,11-14,17-20,30-32,34-35,45-53,70-71,82-83H,4,9-10,15-16,21-29,33H2,1-3H3,(H,67,72)(H,68,92)(H,73,84)(H,74,86)(H,75,88)(H,76,91)(H,77,87)(H,78,90)(H,79,85)(H,80,89)(H4,65,66,69)/t45-,46-,47-,48-,49+,50-,51-,52-,53-/m0/s1

InChIKey

GJKXGJCSJWBJEZ-XRSSZCMZSA-N

LogP

-0.5505300000000017

Topological Polar Surface Area

444.82999999999987 Ų

Hydrogen Bond Donor/Acceptor

18 / 29

Complexity

2610

Synonyms & References

English

  • 57773-65-6
  • Deslorelinum (INN-Latin)
  • Deslorellin acetate
  • 6-Trp-9-N-Et-Pro-10-des-GlyNH2-LHRH
  • DESLORELIN [WHO-DD]
  • LHRH, Trp(6)-N-Et-ProNH2(9)-
  • DESLORELIN (MART.)
  • DESLORELIN [USAN]
  • (D-Trp(sup 6)-pro(sup 9))-LHRH ethylamide
  • CHEBI:177570
  • Deslorelin [USAN:INN:BAN]
  • (D-Trp6,Pro9-NHEt)LH-RH
  • Desloreline (INN-French)
  • SCHEMBL59413
  • SCHEMBL19409316
  • GTPL9343
  • DTXCID0028298
  • MFCD00167401
  • DTXSID2048323
  • NCGC00167516-02
  • NCGC00167516-03
  • Deslorelinum
  • (de-Gly10,D-Trp6,Pro-NHEt)-LH-RH
  • HS-2009
  • AC-8917
  • [des-Gly10, D-Trp6]-LH-RH ethylamide, >=97% (HPLC)
  • BDBM84726
  • DESLORELIN [MI]
  • Deslorelina (INN-Spanish)
  • Bachem 9022
  • GNRH (D-Trp6,pro9-net)

MDL Number

MFCD00167401

FAQ

What regulatory guidelines apply to 5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-tryptophyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide (CAS: 57773-65-6)?

This compound, CAS 57773-65-6, falls under the scope of various regulatory guidelines including the Globally Harmonized System (GHS) for classification and labeling of chemicals, REACH regulations for EU chemicals, and FDA and EPA requirements for pharmaceutical and biological substances. Specific handling, storage, and disposal protocols must be adhered to ensure safety in production and use.

Are there alternatives to 5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-tryptophyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide (CAS: 57773-65-6) in synthesis?

There are several alternatives that can be used in the synthesis of similar compounds, such as analogs with different amino acid sequences or isomers. Common alternative reagents include other cyclic peptides or peptidomimetics that can serve similar biological functions. It is important to consider the specific requirements of the target application when selecting an alternative.

What is the market or research trend for 5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-tryptophyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide (CAS: 57773-65-6)?

The market for this compound is largely driven by its potential applications in pharmaceuticals and biomedical research. Recent trends indicate increased interest in cyclic peptides as therapeutic agents due to their specificity and reduced immunogenicity. Research is also exploring the use of such compounds in targeted drug delivery systems and as model compounds for studying protein-protein interactions.

How should waste containing 5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-tryptophyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide (CAS: 57773-65-6) be handled?

Waste containing this compound should be handled in accordance with local and international environmental regulations. Typically, such waste should be collected in appropriate containers, labeled, and stored under controlled conditions to prevent degradation or contamination. For disposal, professional waste management services that comply with regulatory standards should be used, and incineration may be a suitable method depending on local regulations and the specific hazards of the waste.

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