Triptorelin | CAS No. 57773-63-4

Triptorelin

Basic Information

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CAS Number

57773-63-4

Molecular Formula

C64H82N18O13

Molecular Weight

1311.47 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Specific Rotation

D23 -58.8° (c = 0.33 in acetic acid)

SMILES

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CC(C)CC(C(=O)NC(CCCN=C(N)N)C(=O)N1CCCC1C(=O)NCC(=O)N)NC(=O)C(CC2=CNC3=CC=CC=C32)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(CO)NC(=O)C(CC5=CNC6=CC=CC=C65)NC(=O)C(CC7=CN=CN7)NC(=O)C8CCC(=O)N8

InChI

InChI=1S/C64H82N18O13/c1-34(2)23-46(56(88)75-45(13-7-21-69-64(66)67)63(95)82-22-8-14-52(82)62(94)72-31-53(65)85)76-58(90)48(25-36-28-70-42-11-5-3-9-40(36)42)78-57(89)47(24-35-15-17-39(84)18-16-35)77-61(93)51(32-83)81-59(91)49(26-37-29-71-43-12-6-4-10-41(37)43)79-60(92)50(27-38-30-68-33-73-38)80-55(87)44-19-20-54(86)74-44/h3-6,9-12,15-18,28-30,33-34,44-52,70-71,83-84H,7-8,13-14,19-27,31-32H2,1-2H3,(H2,65,85)(H,68,73)(H,72,94)(H,74,86)(H,75,88)(H,76,90)(H,77,93)(H,78,89)(H,79,92)(H,80,87)(H,81,91)(H4,66,67,69)/t44-,45-,46-,47-,48+,49-,50-,51-,52-/m0/s1

InChIKey

VXKHXGOKWPXYNA-PGBVPBMZSA-N

LogP

-2.085130000000012

Topological Polar Surface Area

487.9199999999999 Å²

Hydrogen Bond Donor/Acceptor

20 / 31

Complexity

2710

Safety Information

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GHS Hazard Pictograms

H302

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

Synonyms & References

English

AKOS030213249
6-D-tryptophan-LH-RH
Triptorelin (USAN/INN)
Diphereline
Triptoreline [INN-French]
Salvacyl
D-Trp6-LHRH
Triptorelin [USAN:INN:BAN]
Wy-42462
D-Tryptophan-LH-RH
BIM-21003
[D-Trp6]-LH-RH, >=97% (HPLC), powder
LHRH, Trp(6)-
CL 118,532
Triptorelina [INN-Spanish]
Q1992452
Debio-8206
Pamorelin LA
GnRH, Trp(6)-
HY-12551
TRIPTORELIN (MART.)
(D-Trp6)-LH-RH
NCGC00167301-02
Trellasar
AS-71149
NCGC00167301-01
BIM 21003
TRIPTORELIN
AY 25650
Triptoreline (INN-French)
VXKHXGOKWPXYNA-PGBVPBMZSA-N

MDL Number

MFCD00167541

FAQ

What are the physical and chemical properties of Triptorelin (CAS: 57773-63-4)?

Triptorelin is a polypeptide with a molecular weight of approximately 1521.47 g/mol. It forms a crystalline solid with a melting point around 190°C. Triptorelin is slightly soluble in water and ethanol but insoluble in organic solvents like hexane. The compound is stable under normal storage conditions but may degrade under acidic or basic conditions.

How is Triptorelin (CAS: 57773-63-4) typically synthesized?

Triptorelin is synthesized via solid-phase peptide synthesis (SPPS). Commonly, the reaction involves coupling of amino acids using Fmoc chemistry and protecting groups. The final step typically includes deprotection and cleavage from the resin using trifluoroacetic acid (TFA). The overall yield is around 50-70%, with high selectivity towards the desired product.

What industries use Triptorelin (CAS: 57773-63-4)?

Triptorelin is primarily used in the pharmaceutical industry for its therapeutic applications, particularly in the treatment of prostate cancer and endometriosis. It is also utilized in research for hormone receptor studies and in the development of hormone-based therapies. Additionally, it has some applications in veterinary medicine and diagnostic imaging.

What precautions should be taken when handling Triptorelin (CAS: 57773-63-4)?

When handling Triptorelin, it is essential to wear appropriate personal protective equipment (PPE) including gloves, safety glasses, and a lab coat. Work should be conducted under a fume hood to minimize inhalation risks. Spills should be handled using appropriate absorbent materials and the area should be cleaned thoroughly. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal procedures.