Naftopidil | CAS No. 57149-07-2

Naftopidil

Basic Information

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CAS Number

57149-07-2

Molecular Formula

C24H28N2O3

Molecular Weight

392.5 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Melting Point

125.0 to 129.0 deg-C

Boiling Point

602.8°C at 760 mmHg

Density

1.1592 (rough estimate)

Flash Point

318.3 °C

Solubility

methanol: >10 mg/mL

Refractive Index

1.6300 (estimate)

SMILES

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COC1=CC=CC=C1N2CCN(CC2)CC(COC3=CC=CC4=CC=CC=C43)O

InChI

InChI=1S/C24H28N2O3/c1-28-24-11-5-4-10-22(24)26-15-13-25(14-16-26)17-20(27)18-29-23-12-6-8-19-7-2-3-9-21(19)23/h2-12,20,27H,13-18H2,1H3

InChIKey

HRRBJVNMSRJFHQ-UHFFFAOYSA-N

LogP

3.410300000000002

Topological Polar Surface Area

45.17 Å²

Hydrogen Bond Donor/Acceptor

1 / 5

Complexity

483

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Toxicity

LD50 in mice, rats (g/kg): 1.3, 6.4 orally (Himmel)

Synonyms & References

English

HMS2051B09
NSC759293
s2126
SMR000466346
UNII-R9PHW59SFN
naftopidil
1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-naphthalen-1-yloxypropan-2-ol
NCGC00015718-04
NSC-759293
cid_6603044
(RS)-1-(4-(2-methoxyphenyl)-1-piperazinyl)-3-(1-naphthyloxy)-2-propanol
BN164631
AB00514643
SPBio_002920
Naftopidilum
Prestwick1_000975
AB00489961-19
MFCD11046013
BDBM50773
BRN 0629965
(+-)-1-(4-(2-Methoxyphenyl)piperazinyl)-3-(1-naphthyloxy)propan-2-ol
BSPBio_001009
1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphthalenyloxy)-2-propanol;hydrochloride
NCGC00015718-12
HMS2089G07
Naftopidil,(S)
HMS3884P07
CHEMBL142635
AKOS002279617
AB00489961_20
1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphthalenyloxy)-2-propanol

MDL Number

MFCD00242741

Customs Code

2942000000

FAQ

What is Naftopidil (CAS: 57149-07-2)?

Naftopidil is a chemical compound with the CAS number 57149-07-2. It is a white crystalline powder that is soluble in water and ethanol. Naftopidil is known for its alpha-1 adrenergic receptor antagonist properties and is commonly used in pharmaceutical applications. Its molecular formula is C15H19NO2, and it has a molecular weight of 253.32 g/mol.

What are the main uses of Naftopidil (CAS: 57149-07-2)?

Naftopidil is primarily used as a medication for the treatment of benign prostatic hyperplasia (BPH) and hypertension. It functions by relaxing smooth muscle in the prostate and bladder, improving urinary flow, and reducing blood pressure. Additionally, it has applications in research for studying vascular and urological conditions.

Is Naftopidil (CAS: 57149-07-2) safe?

Naftopidil is generally considered safe when used as directed in medical and research contexts. However, it should be handled with care, and appropriate safety measures should be followed to avoid exposure. Safety standards for Naftopidil are in place to ensure proper use and minimize risks, particularly in pharmaceutical and industrial settings.

How should Naftopidil (CAS: 57149-07-2) be stored?

Naftopidil should be stored in a cool, dry place away from direct light. It is typically kept in a tightly sealed container to maintain its stability and prevent degradation. Proper storage conditions ensure the compound remains effective and safe for use, with a recommended temperature range of 15-25°C and low humidity levels.