N,N-dimethyl-1-(1H-pyrrolo[2,3-b]pyridin-3-yl)methanamine

Basic Information

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CAS Number

5654-92-2

Molecular Formula

C10H13N3

Molecular Weight

175.23 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Melting Point

144-149 °C

Boiling Point

304.2°Cat760mmHg

Density

1.155

Flash Point

137.8°C

Refractive Index

1.643

SMILES

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CN(C)CC1=CNC2=C1C=CC=N2

InChI

InChI=1S/C10H13N3/c1-13(2)7-8-6-12-10-9(8)4-3-5-11-10/h3-6H,7H2,1-2H3,(H,11,12)

InChIKey

RFLCFQLBXWLHKX-UHFFFAOYSA-N

LogP

1.6245

Topological Polar Surface Area

31.92 Å²

Hydrogen Bond Donor/Acceptor

1 / 3

Complexity

170

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H318 Causes serious eye damage
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

BG-0217
3-(Dimethylaminomethyl)-7-azaindole
SY065890
J-523245
3-(N,N-dimethylaminomethyl)-1H-pyrrolo[2,3-b]pyridine
MFCD01580034
3-dimethylaminomethyl-1H-pyrrolo[2,3-b]pyridine
AKOS015892057
1H-PYRROLO[2,3-B]PYRIDINE-3-METHANAMINE, N,N-DIMETHYL-
NSC173968
NSC-173968
DIMETHYL-(1H-PYRROLO[2,3-B]-3-PYRIDINYLMETHYL)AMINE
AB09285
3-(DIMETHYLAMINOMETHYL)-1H-PYRROLO[2,3-B]PYRIDINE
3-(Dimethylaminomethyl)-7-azaindole, 97%
FT-0647191
1-(2,9-diazabicyclo[4.3.0]nona-2,4,7,10-tetraen-7-yl)-N,N-dimethyl-methanamine
CS-B0513
N,N-dimethyl(1H-pyrrolo[2,3-b]pyridin-3-yl)methanamine
N,N-Dmethyl(1H-Pyrrolo[2,3-b]pyrdn-3-yl)methanamne
F30224
dimethyl({1H-pyrrolo[2,3-b]pyridin-3-ylmethyl})amine
N,N-Dimethyl-1-(1H-pyrrolo[2,3-b]pyridin-3-yl) methanamine
7-azagramine
SCHEMBL46562
dimethyl({1H-pyrrolo[2,3-b]pyridin-3-yl}methyl)amine
N,N-dimethyl-1-(1H-pyrrolo[2,3-b]pyridin-3-yl)methanamine
dimethyl-(1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)-amine
5654-92-2
DTXSID10419386
N,N-Dimethyl-1-(1H-pyrrolo[2,3-b]pyridin-3-yl)-methanamine

MDL Number

MFCD01580034

FAQ

What are the physical and chemical properties of N,N-dimethyl-1-(1H-pyrrolo[2,3-b]pyridin-3-yl)methanamine (CAS: 5654-92-2)?

N,N-dimethyl-1-(1H-pyrrolo[2,3-b]pyridin-3-yl)methanamine is a crystalline solid with a molecular weight of approximately 266.33 g/mol. Its solubility in water is low, and it is more soluble in organic solvents like dimethylformamide (DMF) and dimethyl sulfoxide (DMSO). This compound shows moderate reactivity, particularly towards nucleophiles and bases. It can form stable solutions in common organic solvents, making it suitable for various chemical reactions.

How is N,N-dimethyl-1-(1H-pyrrolo[2,3-b]pyridin-3-yl)methanamine (CAS: 5654-92-2) typically synthesized?

N,N-Dimethyl-1-(1H-pyrrolo[2,3-b]pyridin-3-yl)methanamine is typically synthesized via the condensation of 3-(dimethylamino)pyrrolo[2,3-b]pyridine with ethyl chloroformate in the presence of a base like triethylamine. The reaction is carried out in an aprotic solvent such as N,N-dimethylformamide (DMF) and proceeds through a nucleophilic substitution mechanism, yielding the target compound with good yield and selectivity.

What industries use N,N-dimethyl-1-(1H-pyrrolo[2,3-b]pyridin-3-yl)methanamine (CAS: 5654-92-2)?

N,N-Dimethyl-1-(1H-pyrrolo[2,3-b]pyridin-3-yl)methanamine finds applications in the pharmaceutical industry for its potential use as a precursor in the synthesis of bioactive compounds. It is also used in the polymer industry for developing novel materials with specific properties. Additionally, it has potential uses in the sensor and semiconductor industries due to its electronic and optical properties.

What precautions should be taken when handling N,N-dimethyl-1-(1H-pyrrolo[2,3-b]pyridin-3-yl)methanamine (CAS: 5654-92-2)?

When handling N,N-dimethyl-1-(1H-pyrrolo[2,3-b]pyridin-3-yl)methanamine, it is essential to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or fume hood. Spills should be cleaned up immediately using appropriate absorbents. Always refer to the safety data sheet (SDS) for the latest handling and storage instructions to ensure safe laboratory operations.