Epirubicin hydrochloride

Basic Information

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CAS Number

56390-09-1

Molecular Formula

C27H30ClNO11

Molecular Weight

579.99 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ketones

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Melting Point

185°C

Boiling Point

810.3°C at 760 mmHg

Density

1.61g/cm3

Flash Point

443.8℃

Solubility

Soluble in DMSO to 100mM, or in ethanol to 10mM

Specific Rotation

274° (c=0.01, in methanol)

SMILES

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OCC(=O)[C@@]1(O)C[C@H](O[C@H]2C[C@H](N)[C@H]([C@@H](O2)C)O)c2c(C1)c(O)c1c(c2O)C(=O)c2c(C1=O)cccc2OC.Cl

InChI

InChI=1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22-,27-;/m0./s1

InChIKey

MWWSFMDVAYGXBV-FGBSZODSSA-N

LogP

0.4231000000000001

Topological Polar Surface Area

206.06999999999996 Å²

Hydrogen Bond Donor/Acceptor

7 / 12

Complexity

977

Safety Information

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GHS Hazard Pictograms

H302

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

Synonyms & References

English

Epirubicin HCl
epirubicin hydrochloride
l-erythro-dihydrosphingosine
4'-Epidoxorubicin hydrochloride
5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-.α.-L-arabino-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride
Epirubicin (hydrochloride)
Epirubicin, Hydrochloride Salt (4'-Epidoxorubicin,Pharmorubicin®, Ellence®, Epirubicin Ebewe®, Pharmorubicin,Ridorubicin)
(8S-cis)-10-[(3-Amino-2,3,6-trideoxy-alpha-L-arabino-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphthacene-5,12-dione hydrochloride
(7S,9S)-7-[(2R,4R,5R)-4-Amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-
Epirubicin hydrochloride
(8S,10S)-10-(((2R,4S,5R,6S)-4-Amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione
hydrochloride (1:1)

MDL Number

MFCD00274554

FAQ

What is Epirubicin hydrochloride (CAS: 56390-09-1)?

Epirubicin hydrochloride (CAS: 56390-09-1) is an anthracycline chemotherapy drug used to treat various cancers. Its chemical formula is C28H29NO13·HCl, and it appears as a white crystalline powder. It is known for its ability to interfere with DNA replication and is commonly administered intravenously for its antitumor properties.

What are the main uses of Epirubicin hydrochloride (CAS: 56390-09-1)?

Epirubicin hydrochloride (CAS: 56390-09-1) is primarily used in oncology to treat breast cancer, lymphoma, and other solid tumors. It is also employed in combination therapy for certain types of leukemia and gastrointestinal cancers. As a derivative of doxorubicin, it is valued for its efficacy in targeting rapidly dividing cancer cells.

Is Epirubicin hydrochloride (CAS: 56390-09-1) safe?

Epirubicin hydrochloride (CAS: 56390-09-1) is a potent chemotherapy agent and must be handled with care. It can cause side effects like myelosuppression and cardiotoxicity, requiring strict safety protocols. Always follow guidelines from regulatory bodies such as the FDA and EMA to ensure safe administration and storage.

How should Epirubicin hydrochloride (CAS: 56390-09-1) be stored?

Epirubicin hydrochloride (CAS: 56390-09-1) should be stored in a cool, dry place (2-8°C), protected from light and moisture. Keep in a sealed container to maintain stability and prevent degradation. Avoid exposure to heat and ensure proper labeling for safe handling and storage.