2,2-Dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)-2-propanyl]acetamide

Basic Information

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CAS Number

56-75-7

Molecular Formula

C11H12Cl2N2O5

Molecular Weight

323.13 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Physical State

Powder

Melting Point

149.0 to 153.0 deg-C

Boiling Point

644.9±55.0 °C at 760 mmHg

Water Solubility

2.5 g/L (25 º C)

Flash Point

14 °C

Solubility

absolute ethanol: soluble5-20mg/mL (as a stock solution)

Refractive Index

20 ° (C=5, EtOH)

Vapor Pressure

0.0±2.0 mmHg at 25°C

Specific Rotation

19.5 º (c=6, EtOH)

SMILES

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c1cc(ccc1[C@H]([C@@H](CO)NC(=O)C(Cl)Cl)O)[N+](=O)[O-]

InChI

InChI=1S/C11H12Cl2N2O5/c12-10(13)11(18)14-8(5-16)9(17)6-1-3-7(4-2-6)15(19)20/h1-4,8-10,16-17H,5H2,(H,14,18)/t8-,9-/m1/s1

InChIKey

WIIZWVCIJKGZOK-RKDXNWHRSA-N

LogP

1.82310

Complexity

342

Safety Information

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GHS Hazard Pictograms

H350

Hazard Statement

H350 May cause cancer
Carcinogenicity

Hazard Class

Class 9 Class 9

Storage Conditions

2-8℃

Synonyms & References

English

chloroamphenicol
chloramphenicol
2,2-dichloro-n-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]acetamide
d-(-)-threo-2,2-dichloro-n-[beta-hydroxy-alpha-(hydroxy-methyl)-p-nitrophenethyl]acetamide
chloromycetin
(R,R)-Chloramphenicol
Chloramphenicol (Chloromycetin)
CHLORAMPHENICOL(P)
ISOPROPYLMAGNESIUM CHLORIDE LITHIUM CHL&
(-)-Chloramphenicol
2,2-dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide
2,2-dichloro-N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]acetamide
Ambofen
amphemycin
CAF
Catilan
Chlomin
chloramfenicol
comycetin
D-(?)-threo-1-p-nitrophenyl-2-dichloracetamido-1,3-propanediol
Enicol
i337a
Mychel
u-6062
D-(-)-threo-2-Dichloroacetamido-1-(4-nitrophenyl)-1,3-propanediol
2,2-Dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)-2-propyl]acetamide
comycetin。
Chlornitromycin
Levomycetin
Levomicetina
Halomycetin

MDL Number

MFCD00078159

Customs Code

2941400000

FAQ

What is 2,2-Dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)-2-propanyl]acetamide (CAS: 56-75-7)?

2,2-Dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)-2-propanyl]acetamide (CAS: 56-75-7), also known as Chloramphenicol, is a broad-spectrum antibiotic with a complex molecular structure. It inhibits bacterial protein synthesis by targeting the 50S ribosomal subunit. Chloramphenicol is effective against Gram-positive and Gram-negative bacteria, including *Staphylococcus* and *Escherichia coli*. Its chemical formula is C11H12Cl2N2O5, and it appears as a white crystalline powder with low solubility in water. It is widely used in pharmaceuticals and veterinary medicine due to its potent antimicrobial activity.

What are the main uses of 2,2-Dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)-2-propanyl]acetamide (CAS: 56-75-7)?

2,2-Dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)-2-propanyl]acetamide (CAS: 56-75-7), or Chloramphenicol, is primarily used as an antibiotic to treat bacterial infections in humans and animals. It is also applied in veterinary medicine for livestock and poultry. In research, it serves as a key compound for studying antibiotic mechanisms. Additionally, it has industrial applications in chemical synthesis and as a preservative in certain formulations. Its versatility makes it a critical component in pharmaceutical and scientific fields.

Is 2,2-Dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)-2-propanyl]acetamide (CAS: 56-75-7) safe?

2,2-Dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)-2-propanyl]acetamide (CAS: 56-75-7), known as Chloramphenicol, requires careful handling due to potential toxicity. Prolonged use may cause bone marrow suppression and gray baby syndrome in newborns. Safety standards emphasize proper protective gear, such as gloves and goggles, during handling. It is classified as a restricted substance in many regions, necessitating adherence to regulatory guidelines to ensure safe use in medical and industrial contexts.

How should 2,2-Dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)-2-propanyl]acetamide (CAS: 56-75-7) be stored?

2,2-Dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)-2-propanyl]acetamide (CAS: 56-75-7) should be stored in a cool, dry place away from light. Maintain humidity levels below 60% to prevent degradation. Use airtight, light-resistant containers such as amber glass bottles to protect its chemical stability. Store in a secure location to avoid exposure to moisture or heat, ensuring its potency and safety for extended periods.