(5alpha)-17-(Cyclopropylmethyl)-6-methylene-4,5-epoxymorphinan-3,14-diol | CAS No. 55096-26-9

(5alpha)-17-(Cyclopropylmethyl)-6-methylene-4,5-epoxymorphinan-3,14-diol

Basic Information

CAS Number

55096-26-9

Molecular Formula

C21H25NO3

Molecular Weight

339.44 g/mol

AD

Basic Physical Properties

Melting Point

182-185?C

C=C1CCC2(C3CC4=C5C2(C1OC5=C(C=C4)O)CCN3CC6CC6)O

InChI

InChI=1S/C21H25NO3/c1-12-6-7-21(24)16-10-14-4-5-15(23)18-17(14)20(21,19(12)25-18)8-9-22(16)11-13-2-3-13/h4-5,13,16,19,23-24H,1-3,6-11H2/t16-,19+,20+,21-/m1/s1

InChIKey

WJBLNOPPDWQMCH-MBPVOVBZSA-N

LogP

2.512500000000001

Topological Polar Surface Area

52.93000000000001 Ų

Hydrogen Bond Donor/Acceptor

2 / 4

Complexity

618

Synonyms & References

English

  • Nalmefeno
  • Nalmetrenum
  • ORF 1167
  • PDSP2_001543
  • SRD-174
  • 9a-(Cyclopropylmethyl)-4,5alpha-epoxy-6-methylen-3,14-morphinandiol
  • MLS000069366
  • CHEBI:7457
  • SCHEMBL35230
  • EN300-18384909
  • Revex (nalmefene hydrochloride)
  • UNII-TOV02TDP9I
  • Tox21_110873
  • SRD174
  • NCGC00021666-03
  • CHEMBL982
  • Selincro (TN)
  • NALMEFENE [INN]
  • NALMEFENE [VANDF]
  • (5alpha)-17-(Cyclopropylmethyl)-4,5-epoxy-6-methylenemorphinan-3,14-diol
  • (4R,4aS,7aS,12bS)-3-(cyclopropylmethyl)-7-methylidene-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,9-diol
  • Revex
  • NALMEFENE [USAN]
  • Nalmetreno (INN-Spanish)
  • WJBLNOPPDWQMCH-MBPVOVBZSA-N
  • DB06230
  • (1S,5R,13S,17S)-4-(cyclopropylmethyl)-14-methylidene-12-oxa-4-azapentacyclo[9.6.1.0^{1,13}.0^{5,17}.0^{7,18}]octadeca-7,9,11(18)-triene-10,17-diol
  • Nalmetreno
  • HMS2232D07
  • NALMEFENE [HSDB]
  • BCP16723

MDL Number

MFCD00133650

FAQ

What regulatory guidelines apply to (5alpha)-17-(Cyclopropylmethyl)-6-methylene-4,5-epoxymorphinan-3,14-diol (CAS: 55096-26-9)?

This compound is regulated under the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) and requires proper labeling for health and environmental hazards. Additionally, under the European Union’s REACH regulation, it must be reported if used above certain thresholds. FDA and EPA have requirements for its safe handling, storage, and disposal, mainly focusing on its potential for abuse and environmental impact.

Are there alternatives to (5alpha)-17-(Cyclopropylmethyl)-6-methylene-4,5-epoxymorphinan-3,14-diol in synthesis?

Yes, there are alternative reagents and routes that can be used, such as using morphine or other 3,14-diol compounds as starting materials. Isomers like (6alpha)-methylene-4,5-epoxymorphinan-3,14-diol can also serve as alternatives, but they may require different synthetic strategies and conditions.

What is the market or research trend for (5alpha)-17-(Cyclopropylmethyl)-6-methylene-4,5-epoxymorphinan-3,14-diol?

Research trends for this compound are focused on its potential as a therapeutic agent for pain management and addiction treatment. Market trends suggest increasing demand in pharmaceuticals, driven by ongoing clinical trials and regulatory approvals. However, due to its controlled status, market growth is tightly regulated and heavily scrutinized.

How should waste containing (5alpha)-17-(Cyclopropylmethyl)-6-methylene-4,5-epoxymorphinan-3,14-diol (CAS: 55096-26-9) be handled?

Waste containing this compound should be collected in properly labeled containers and stored in a secure area. Incineration or professional waste disposal services are recommended. Environmental protection measures include preventing the waste from entering water bodies and ensuring all necessary permits are obtained. Proper disposal methods are crucial to prevent environmental contamination and ensure compliance with regulatory requirements.

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