Andrographolide

Basic Information

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CAS Number

5508-58-7

Molecular Formula

C20H30O5

Molecular Weight

350.46 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Melting Point

229.0 to 235.0 deg-C

Boiling Point

557.3 °C at 760 mmHg

Flash Point

557.3 °C at 760 mmHg

Solubility

Methanol,DMSO,Water

Refractive Index

1.567

Specific Rotation

-126 º (c=1.5,HAc)

SMILES

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O[C@@H]([C@](C)([C@@](CC1)2[H])CO)CC[C@@]2(C)[C@H](C/C=C([C@@H](CO3)O)/C3=O)C1=C

InChI

InChI=1S/C20H30O5/c1-12-4-7-16-19(2,9-8-17(23)20(16,3)11-21)14(12)6-5-13-15(22)10-25-18(13)24/h5,14-17,21-23H,1,4,6-11H2,2-3H3/b13-5+/t14-,15-,16+,17-,19+,20+/m1/s1

InChIKey

BOJKULTULYSRAS-OTESTREVSA-N

LogP

1.9626

Topological Polar Surface Area

86.99000000000001 Å²

Hydrogen Bond Donor/Acceptor

3 / 5

Complexity

597

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H332 Harmful if inhaled
Acute toxicity, inhalation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Storage Conditions

-20℃

Synonyms & References

English

Andrographolide
ANDRO
ANDROGRAPHIS
3A,14,15,18-TETRAHYDROXY-5B,9B,H,10A-LAMBDA-8,20-DIENE
2(3H)-FURANONE,3-[2-[(1R,4AS,5R,6R,8AS)-DECAHYDRO-6-HYDROXY-5-(HYDROXYMETHYL)-5,8A-DIMETHYL-2-METHYLENE-1-NAPHTHALENYL]ETHYLIDENE]DIHYDRO-4-HYDROXY-, (3E,4S)-
2(3h)-furanone,3-(2-(decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-met
hylene-1-naphthalenyl)ethylidene)dihydro-4-hydroxy-,(1r-(1-alpha(e(s*)),4a-be
(S,E)-4-Hydroxy-3-(2-((1R,4aS,5R,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenedecahydronaphthalen-1-yl)ethylidene)dihydrofuran-2(3H)-one
ANDROGRAPHOLIDE(P)
ANDROGRAPHOLIDE(SH) PrintBack
alpha-Chloro-p-xylene
Andrographalide
Andrographolid
Rhizoma Sparganii
(3E,4S)-3-[2-[(1R,4aS,5R,6R,8aS)-Decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]dihydro-4-hydroxy-2(3H)-furanone
ent-(3β,12E,14R)-3,14,19-Trihydroxy-8(17),12-labdadien-16,15-olide
andrographolidume
[ "" ]
410105JHGR
Andropanolide
3-(2-(Decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenenaphthyl)ethylidene)dihydro-4-hydroxyfuran-2(3H)-one
(3E,4S)-4-hydroxy-3
Andrographis
Andrographis,Andrographolid,Andrographiside aglycon

MDL Number

MFCD07778082

Customs Code

29322980

FAQ

What is Andrographolide (CAS: 5508-58-7)?

Andrographolide is a diterpenoid lactone compound derived from the plant Andrographis paniculata. It has a molecular formula of C19H28O6 and is known for its bitter taste. This natural product exhibits various pharmacological properties, including anti-inflammatory and antimicrobial effects. It is commonly used in traditional medicine and has gained attention for its potential therapeutic applications in modern research.

What are the main uses of Andrographolide (CAS: 5508-58-7)?

Andrographolide is primarily used in pharmaceuticals for its anti-inflammatory, antimicrobial, and antiviral properties. It is found in traditional herbal remedies and is being studied for its potential in treating infections and inflammatory diseases. Additionally, it is used in research for drug development and as a bioactive compound in natural product studies.

Is Andrographolide (CAS: 5508-58-7) safe?

Andrographolide is generally considered safe when used as directed, but it should be handled with care. It is classified as a natural compound with low toxicity, but some studies suggest potential side effects such as gastrointestinal discomfort. Safety standards recommend proper storage and handling to ensure its stability and effectiveness in research and medicinal applications.

How should Andrographolide (CAS: 5508-58-7) be stored?

Andrographolide should be stored in a cool, dry place away from direct light. It is best kept in a sealed container at a temperature of 2-8°C to maintain its stability and potency. Proper storage conditions are essential to prevent degradation and ensure the compound remains effective for both research and pharmaceutical uses.