6-Chloro-1H-pyrrolo[2,3-b]pyridine

Basic Information

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CAS Number

55052-27-2

Molecular Formula

C7H5ClN2

Molecular Weight

152.58 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Physical State

White to Yellow Solid

Melting Point

175-180°C

SMILES

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C1=CC(=NC2=C1C=CN2)Cl

InChI

InChI=1S/C7H5ClN2/c8-6-2-1-5-3-4-9-7(5)10-6/h1-4H,(H,9,10)

InChIKey

DSCOSIUAQUDGJM-UHFFFAOYSA-N

LogP

2.2162999999999995

Topological Polar Surface Area

28.68 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Complexity

129

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class 6.1 Class 6.1

Synonyms & References

English

6-Chloro-1H-pyrrolo[2,3-b]pyridine, AldrichCPR
FT-0649499
AKOS004910657
6-CHLORO-1H-PYRROLO[2,3-B]PYRIDINE
MFCD06659666
A7981
SY007157
6-Chloro-7-azaindole
J-518498
BCP26599
PB21926
EN300-99882
SCHEMBL10776
CS-B0094
DSCOSIUAQUDGJM-UHFFFAOYSA-N
AS-17858
7-aza-6-chloroindole
DTXSID20462909
1H-Pyrrolo[2,3-b]pyridine, 6-chloro-
6-Chloro-1H-pyrrolo[2 pound not3-b]pyridine
A830463
55052-27-2
6-chloranyl-1H-pyrrolo[2,3-b]pyridine
AM20061314
6-Chloro-1H-pyrrolo[2,3-b]pyridine
PubChem18673
KSC494A8J
HIN1528
HT743
STL555194
RW3761

MDL Number

MFCD06659666

Customs Code

2933990090

FAQ

What are the physical and chemical properties of 6-Chloro-1H-pyrrolo[2,3-b]pyridine (CAS: 55052-27-2)?

6-Chloro-1H-pyrrolo[2,3-b]pyridine is a crystalline solid with a molecular weight of approximately 195.57 g/mol. It has a low solubility in water but is more soluble in organic solvents like dimethylformamide (DMF) and acetonitrile. Chemically, it is reactive, particularly towards nucleophiles, and can undergo substitution reactions at the chlorine atom.

How is 6-Chloro-1H-pyrrolo[2,3-b]pyridine (CAS: 55052-27-2) typically synthesized?

6-Chloro-1H-pyrrolo[2,3-b]pyridine is typically synthesized via a multistep process, starting with the reaction of chloroacetyl chloride with pyrrole. The process often involves the use of a base like sodium hydride and requires careful control of reaction conditions to achieve high yield and selectivity.

What industries use 6-Chloro-1H-pyrrolo[2,3-b]pyridine (CAS: 55052-27-2)?

6-Chloro-1H-pyrrolo[2,3-b]pyridine is mainly used in the pharmaceutical industry for the development of medicinal compounds. It is also utilized in the chemical sensor industry due to its reactivity and ability to interact with specific analytes. Additionally, it finds applications in the semiconductor industry for its electronic properties.

What precautions should be taken when handling 6-Chloro-1H-pyrrolo[2,3-b]pyridine (CAS: 55052-27-2)?

When handling 6-Chloro-1H-pyrrolo[2,3-b]pyridine, safety measures such as the use of personal protective equipment (PPE) including gloves and safety goggles are essential. The compound should be handled in a well-ventilated fume hood to avoid inhalation. Spills should be cleaned up using appropriate absorbents, and proper disposal methods should be followed. Always consult the Safety Data Sheet (SDS) for detailed safety information.