6-Chloro-1H-pyrrolo[2,3-b]pyridine(CAS: 55052-27-2)

6-Chloro-1H-pyrrolo[2,3-b]pyridine is a crystalline solid with a molecular weight of approximately 195.57 g/mol. It has a low solubility in water but is more soluble in organic solvents like dimethylformamide (DMF) and acetonitrile. Chemically, it is reactive, particularly towards nucleophiles, and can undergo substitution reactions at the chlorine atom.

6-Chloro-1H-pyrrolo[2,3-b]pyridine is typically synthesized via a multistep process, starting with the reaction of chloroacetyl chloride with pyrrole. The process often involves the use of a base like sodium hydride and requires careful control of reaction conditions to achieve high yield and selectivity.

6-Chloro-1H-pyrrolo[2,3-b]pyridine is mainly used in the pharmaceutical industry for the development of medicinal compounds. It is also utilized in the chemical sensor industry due to its reactivity and ability to interact with specific analytes. Additionally, it finds applications in the semiconductor industry for its electronic properties.

When handling 6-Chloro-1H-pyrrolo[2,3-b]pyridine, safety measures such as the use of personal protective equipment (PPE) including gloves and safety goggles are essential. The compound should be handled in a well-ventilated fume hood to avoid inhalation. Spills should be cleaned up using appropriate absorbents, and proper disposal methods should be followed. Always consult the Safety Data Sheet (SDS) for detailed safety information.