Methyl 2-hydroxy-4-methoxybenzoate

Basic Information

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CAS Number

5446-02-6

Molecular Formula

C9H10O4

Molecular Weight

182.17 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Melting Point

48.0 to 52.0 deg-C

Boiling Point

134°C/7mmHg

Water Solubility

Soluble in acetone. Insoluble in water.

Refractive Index

1.4600 (estimate)

SMILES

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COC1=CC(=C(C=C1)C(=O)OC)O

InChI

InChI=1S/C9H10O4/c1-12-6-3-4-7(8(10)5-6)9(11)13-2/h3-5,10H,1-2H3

InChIKey

ZICRWXFGZCVTBZ-UHFFFAOYSA-N

LogP

1.1874

Topological Polar Surface Area

55.760000000000005 Å²

Hydrogen Bond Donor/Acceptor

1 / 4

Complexity

181

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Synonyms & References

English

EN300-15505
EINECS 226-657-5
methyl 4-methoxy-2-oxidanyl-benzoate
Methyl 4-methoxysalicylate
CS-W009087
2-hydroxy-4-methoxy-benzoic acid methyl ester
Methyl2-hydroxy-4-methoxybenzoate
methyl 4-methoxy-2-hydroxybenzoate
2,4-Cyclohexadien-1-one, 6-(hydroxymethoxymethylene)-3-methoxy-, (6E)-
4-Methoxysalicylic Acid Methyl Ester
NSC17154
methyl 4-methoxy,2-hydroxybenzoate
NSC 17154
5446-02-6
W-105622
SY008082
Z24769843
M1797
NS00044939
Methyl 4-methoxysalicylate, 98%
NSC-17154
Methyl 4-methoxy salicylate
Methyl-4-methoxysalicylate
2-methoxycarbonyl-5-methoxyphenol
Methyl 2-Hydroxy-p-anisate
InChI=1/C9H10O4/c1-12-6-3-4-7(8(10)5-6)9(11)13-2/h3-5,10H,1-2H
PS-6101
DTXSID00202860
CHEMBL502178
FT-0635717
Benzoic acid, 2-hydroxy-4-methoxy-, methyl ester

MDL Number

MFCD00008424

Customs Code

2942000000

FAQ

What are the physical and chemical properties of Methyl 2-hydroxy-4-methoxybenzoate (CAS: 5446-02-6)?

Methyl 2-hydroxy-4-methoxybenzoate (CAS: 5446-02-6) is a crystalline solid with a molecular weight of approximately 214.26 g/mol. It has a melting point of 126-128°C and is soluble in ethanol and methanol. The compound is less soluble in water. It is a weak acid and exhibits limited reactivity under normal conditions.

How is Methyl 2-hydroxy-4-methoxybenzoate (CAS: 5446-02-6) typically synthesized?

Methyl 2-hydroxy-4-methoxybenzoate (CAS: 5446-02-6) is typically synthesized via a condensation reaction between 2-hydroxy-4-methoxybenzoic acid and methanol, catalyzed by a weak acid or a base. The reaction is carried out under mild conditions to achieve good selectivity and yield.

What industries use Methyl 2-hydroxy-4-methoxybenzoate (CAS: 5446-02-6)?

Methyl 2-hydroxy-4-methoxybenzoate (CAS: 5446-02-6) is used in the pharmaceutical industry as an intermediate for the synthesis of active pharmaceutical ingredients. It also finds applications in the polymer industry as a stabilizer and in the sensor industry for its specific chemical reactivity.

What precautions should be taken when handling Methyl 2-hydroxy-4-methoxybenzoate (CAS: 5446-02-6)?

When handling Methyl 2-hydroxy-4-methoxybenzoate (CAS: 5446-02-6), it is important to wear appropriate personal protective equipment (PPE) such as gloves and goggles. The compound should be handled in a well-ventilated area or a fume hood to avoid inhalation. In case of a spill, it should be cleaned up using absorbent materials and disposed of according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed handling instructions.