3-(Dimethylamino)-1-(2-thienyl)-1-propanone hydrochloride (1:1)

Basic Information

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CAS Number

5424-47-5

Molecular Formula

C9H14ClNOS

Molecular Weight

219.74 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ketones

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

176.0 to 182.0 deg-C

Boiling Point

282.6°Cat760mmHg

Density

1.096

Flash Point

124.7℃

SMILES

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CN(C)CCC(=O)C1=CC=CS1.Cl

InChI

InChI=1S/C9H13NOS.ClH/c1-10(2)6-5-8(11)9-4-3-7-12-9;/h3-4,7H,5-6H2,1-2H3;1H

InChIKey

HPVHJPMLORARSR-UHFFFAOYSA-N

LogP

2.304300000000001

Topological Polar Surface Area

20.310000000000002 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Complexity

159

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H317 May cause an allergic skin reaction
Sensitization, Skin

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Sensitiveness

对空气敏感

Synonyms & References

English

2-THIENYL-2-DIMETHYLAMINOETHYL KETONE HCL
2-[3-(Dimethylamino)propionyl]thiopheneHydrochloride
1-Propanone, 3-(dimethylamino)-1-(2-thienyl)-, hydrochloride (1:1); : 1-Propanone, 3-(dimethylamino)-1-(2-thienyl)-, hydrochloride (7CI,9CI); 3-Dimethylamino-1-(2-thienyl)-1-propanone hydrochloride
1-Propanone, 3-(dimethylamino)-1-(2-thienyl)-, hydrochloride
3-(Dimethylamino)-1-(2-thienyl)-1-propanone, HC
2-[3-(Dimethylamino)propionyl]thiophene Hydrochloride
3-(DIMETHYLAMINO)-1-(2-THIENYL)-1-PROPANONE HCL
Cambridge id 5927860
5424-47-5
BIM-0008383.P001
SY004008
3-dimethylamino-1-(2-thienyl)propan-1-one hydrochloride
3-(dimethylamino)-1-thiophen-2-ylpropan-1-one;hydrochloride
3-Dimethylamino-1-thiophen-2-yl-propan-1-one hydrochloride
EN300-6759850
2-thienyl 2-dimethylaminoethyl ketone hydrochloride
Z2941377966
BCP08868
AC-1548
JS-3003
3-(Dimethylamino)-1-(thiophen-2-yl)propan-1-one--hydrogen chloride (1/1)
CS-W010467
3-(Dimethylamino)-1-(2-thienyl)-1-propanone, HCl
AMY8711
D4011
3-Dimethylamino-1-(2-thienyl)-1-propanone hydrochloride
DTXSID50386942
1-Propanone, 3-(dimethylamino)-1-(2-thienyl)-, hydrochloride (1:1)
3-(dimethylamino)-1-(thiophen-2-yl)propan-1-one hydrochloride
MFCD00126349
HPVHJPMLORARSR-UHFFFAOYSA-N

MDL Number

MFCD00126349

Customs Code

2934999090

FAQ

What are the physical and chemical properties of 3-(Dimethylamino)-1-(2-thienyl)-1-propanone hydrochloride (CAS: 5424-47-5)?

3-(Dimethylamino)-1-(2-thienyl)-1-propanone hydrochloride (CAS: 5424-47-5) is a crystalline compound with a molecular weight of approximately 273.4 g/mol. It is sparingly soluble in water but highly soluble in organic solvents like methanol and acetone. Chemically, it is relatively stable but reacts with basic compounds. It is used in various organic synthesis reactions due to its nucleophilic and electrophilic properties.

How is 3-(Dimethylamino)-1-(2-thienyl)-1-propanone hydrochloride (CAS: 5424-47-5) typically synthesized?

3-(Dimethylamino)-1-(2-thienyl)-1-propanone hydrochloride is typically synthesized through a multistep process involving the reaction of 2-thiophenecarboxaldehyde with dimethylamine followed by the addition of hydrochloric acid. The synthesis often requires a catalyst and is carried out under mild conditions to achieve high selectivity and yield. The final product is obtained as a crystalline solid.

What industries use 3-(Dimethylamino)-1-(2-thienyl)-1-propanone hydrochloride (CAS: 5424-47-5)?

3-(Dimethylamino)-1-(2-thienyl)-1-propanone hydrochloride (CAS: 5424-47-5) is primarily used in the pharmaceutical and chemical industries. It serves as a valuable intermediate in the synthesis of various drugs and is also used in the development of sensors and semiconductors due to its unique chemical properties.

What precautions should be taken when handling 3-(Dimethylamino)-1-(2-thienyl)-1-propanone hydrochloride (CAS: 5424-47-5)?

When handling 3-(Dimethylamino)-1-(2-thienyl)-1-propanone hydrochloride (CAS: 5424-47-5), appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn. Work should be conducted in a fume hood to minimize inhalation risks. Spills should be immediately cleaned up with appropriate absorbent materials. Always consult the Safety Data Sheet (SDS) for detailed handling and disposal information.