4-Chloro-1-methylpiperidine hydrochloride (1:1)

Basic Information

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CAS Number

5382-23-0

Molecular Formula

C6H13Cl2N

Molecular Weight

170.08 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Melting Point

161.0 to 166.0 deg-C

Boiling Point

165.7 °C at 760 mmHg

Density

1.04

Water Solubility

very faint turbidity

Flash Point

54 °C

SMILES

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CN1CCC(CC1)Cl.Cl

InChI

InChI=1S/C6H12ClN.ClH/c1-8-4-2-6(7)3-5-8;/h6H,2-5H2,1H3;1H

InChIKey

QDOJNWFOCOWAPO-UHFFFAOYSA-N

LogP

1.7412

Topological Polar Surface Area

3.24 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

66.9

Safety Information

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GHS Hazard Pictograms

H315

H319

H335

Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Sensitiveness

Hygroscopic

Synonyms & References

English

4-Chloro-N-methylpiperidine hydrochloride
Piperidine, 4-chloro-1-methyl-, hydrochloride
DTXSID20202100
AC-15426
1-Methyl-4-chloropiperidinehydrochloride
QDOJNWFOCOWAPO-UHFFFAOYSA-N
NSC-76039
4-Chloro-1-methylpiperidine hydrochloride, 99%
W-105703
n-methyl-4-chloropiperidine hydrochloride
SB41080
A829780
1-Methyl -4- Chloro Piperidine
MFCD00012834
PIPERIDINE, 4-CHLORO-1-METHYL-, HYDROCHLORIDE (1:1
4-chloro-1-methylpiperidine;hydrochloride
4-Chloro-1-methylpiperidine, HCl
NSC76039
NSC 76039
4-Chloro-1-methylpiperidine-d4Hydrochloride
5382-23-0
FT-0618234
4-chloro-1-methyl-piperidine hydrochloride
EINECS 226-375-2
AS-11810
C1085
AKOS005259871
5QDX0Y5PMJ
4-CHLORO-1-METHYLPIPERIDINE HCL
4-Chloro-1-methylpiperidinium chloride
SCHEMBL490234

MDL Number

MFCD00012834

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 4-Chloro-1-methylpiperidine hydrochloride (CAS: 5382-23-0)?

4-Chloro-1-methylpiperidine hydrochloride (CAS: 5382-23-0) is a crystalline solid with a molecular weight of approximately 198.57 g/mol. It has a solubility of about 15 g/L in water and is highly soluble in organic solvents like ethanol. It is stable under normal conditions but may react with strong bases to form 4-chloro-1-methylpiperidine.

How is 4-Chloro-1-methylpiperidine hydrochloride (CAS: 5382-23-0) typically synthesized?

4-Chloro-1-methylpiperidine hydrochloride is typically synthesized by the reaction of 1-methylpiperidine with chlorine gas in the presence of a catalyst such as phosphoric acid. The yield is around 85%, and the product is isolated by recrystallization from water or ethanol.

What industries use 4-Chloro-1-methylpiperidine hydrochloride (CAS: 5382-23-0)?

4-Chloro-1-methylpiperidine hydrochloride (CAS: 5382-23-0) is used primarily in the pharmaceutical industry for the synthesis of various drugs. It is also used in the polymer industry as a monomer for the production of certain polymers, and in the sensor industry for the development of chemical sensors.

What precautions should be taken when handling 4-Chloro-1-methylpiperidine hydrochloride (CAS: 5382-23-0)?

When handling 4-Chloro-1-methylpiperidine hydrochloride (CAS: 5382-23-0), it is crucial to wear appropriate personal protective equipment (PPE) such as gloves and goggles. Work in a well-ventilated area or fume hood to avoid inhalation of vapors. Store in a cool, dry place away from incompatible materials. In case of a spill, neutralize with a base and dispose of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling information.