4-Hydroxybenzhydrazide

Basic Information

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CAS Number

5351-23-5

Molecular Formula

C7H8N2O2

Molecular Weight

152.15 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Melting Point

268°C

Boiling Point

274.61°C (rough estimate)

Solubility

26.5g/l

Refractive Index

1.5200 (estimate)

SMILES

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C1=CC(=CC=C1C(=O)NN)O

InChI

InChI=1S/C7H8N2O2/c8-9-7(11)5-1-3-6(10)4-2-5/h1-4,10H,8H2,(H,9,11)

InChIKey

ZMZGIVVRBMFZSG-UHFFFAOYSA-N

LogP

-0.004300000000000248

Topological Polar Surface Area

75.35000000000001 Å²

Hydrogen Bond Donor/Acceptor

4 / 4

Complexity

141

Safety Information

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GHS Hazard Pictograms

H315

H319

H335

Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Sensitiveness

Susceptible to air oxidation

Synonyms & References

English

AKOS000119735
NSC-647
(4-Hydroxybenzoyl)hydrazine
MLS002153529
NCGC00015528-01
NCGC00093952-01
SR-01000075923
Z57036327
4-Hydroxybenzhydrazide, >=97%
4-Hydroxybenzoic acid, hydrazide
Y4G7G6U5GQ
HMS3062I15
p-Hydroxybenzoyl hydrazide
CHEBI:195425
4-Hydroxybenzhydrazide, suitable for fluorescence, >=97.0% (T)
4-Hydroxybenzoic acid hydrazide
p-hydroxybenzohydrazide
CHEMBL124267
4-hydroxy-benzohydrazide
4-hydroxybenzoate hydrazide
NCGC00093952-02
4-Oxidanylbenzohydrazide
p-hydroxybenzoylhydrazine
SCHEMBL80530
4-hydroxybenzoyl hydrazide
EU-0100568
FT-0618692
NSC647
4-hydroxybenzo hydrazide
BS-3839
4-Hydroxybenzoylhydrazine

MDL Number

MFCD00007605

Customs Code

29280090

FAQ

What are the physical and chemical properties of 4-Hydroxybenzhydrazide (CAS: 5351-23-5)?

4-Hydroxybenzhydrazide (CAS: 5351-23-5) has a crystalline form with a molecular weight of approximately 172.18 g/mol. It has a solubility of about 1.2 g/L in water at 20°C. The compound shows moderate reactivity, primarily through its hydrazide group, and can undergo condensation and substitution reactions.

How is 4-Hydroxybenzhydrazide (CAS: 5351-23-5) typically synthesized?

4-Hydroxybenzhydrazide (CAS: 5351-23-5) can be synthesized through the reduction of 4-hydroxybenzoyl hydrazine under various conditions, such as using sodium borohydride in an aqueous medium. The reaction typically yields a high purity product with good selectivity and moderate yield.

What industries use 4-Hydroxybenzhydrazide (CAS: 5351-23-5)?

4-Hydroxybenzhydrazide (CAS: 5351-23-5) is used in the pharmaceutical industry for the synthesis of certain drugs and in the polymer industry as a precursor for various materials. It also finds applications in the development of sensors and semiconductors due to its functional groups.

What precautions should be taken when handling 4-Hydroxybenzhydrazide (CAS: 5351-23-5)?

When handling 4-Hydroxybenzhydrazide (CAS: 5351-23-5), it is important to wear appropriate personal protective equipment (PPE) such as gloves and safety glasses. Store the compound in a cool, dry place away from direct sunlight and flammable materials. In case of a spill, wear a respirator and use appropriate spill cleanup materials. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions.